Saturday, December 31, 2011

16-year-old computer prodigy's life at risk

This portrait of Arfa Karim Randhawa, by Dan DeLong, accompanied a Seattle P-I story about her 2005 Microsoft visit.

Computer programming prodigy Arfa Karim Randhawa, a?16-year-old girl from?Pakistan who seven years ago became the youngest Microsoft Certified Professional in the world, is on life support after?suffering an epileptic attack, according to a newspaper report out of the country.

Her father,?Amjad Karim Randhawa, tells The Express Tribune,??only a miracle will allow my brilliant, genius daughter to live now."

In 2005, when I was working for the Seattle P-I newspaper, I got a chance to meet and?write a story?about Arfa. She was 10 years old at the time, visiting the Microsoft campus to meet Bill Gates and other executives from the Redmond company.

(Msnbc.com is a joint venture of Microsoft and NBC Universal.)

As I wrote in the story at the time,?She made an impression through a combination of charm, flattery and boldness uncommon for someone her age. For example, during Arfa?s meeting with Gates, she presented him with a poem she wrote that celebrated his life story. But she also questioned him about what she perceived to be the relatively small proportion of women on the?campus.

In short, she is a remarkable person. She is also very thoughtful, and after the article ran, she made a point of keeping in touch with me via email. It was fun to periodically get messages from her out of the blue, updating me on her progress in school and her plans for the future.

Arfa was extremely proud of her accomplishment as the youngest Microsoft Certified Professional, even including the phrase ?Youngest MCP in the World? in her email signature line. So a?few years ago,when a 9-year-old from India broke her record, I sent Arfa a link and asked her what she thought.

I went back this morning and found her response ?

?This is the first time I?ve seen this story. But I must say that I?m really happy to have read it. This is exactly what I had been wishing for ever since I got to bring laurels for my country. I am very glad to see that people are following what I did and have succeeded in beating me. I don?t know whether you?ve heard or not but a boy, named Bilal, from Gujranwala in Pakistan also became a Microsoft Certified Professional at the age of nine. I would say that the other youngsters should follow suit, thereby convincing the people to take us kids seriously. Our generation is very talented and so should be promoted.?

She was 13 at the time, and working hard in school in hopes of attending her ?dream university,? MIT, where she wanted to study computer science.

Todd Bishop is co-founder of GeekWire, a technology news site based in Seattle.

Source: http://digitallife.today.msnbc.msn.com/_news/2011/12/30/9833946-remembering-arfa-seizure-threatens-life-of-16-year-old-computer-prodigy

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Friday, December 30, 2011

Scription Chronodox is a Beautiful, Printable, Freeform Weekly Planner for the New Year [DIY]

Scription Chronodox is a Beautiful, Printable, Freeform Weekly Planner for the New YearTypical planners and diaries force you into a confined grid when planning your day and taking notes. Scription Chronodex breaks that confinement by providing a freeform area to use text, drawings, or whatever to keep track of your days and get things done.

The idea of the Chronodex is a little complicated to understand at first because it does not look like a typical planner or diary (it can be used for either purpose). In the center of most pages you have this circle with wedges protruding from it that represent different times of the day. You can attach your notes to these wedges to assign it a specific time of day or just to mark when something happened. Every other page also provides an overview of the days of the week. The idea is that breaking out of the confinement of the typical grid will allow you the freedom to plan openly. You won't feel the need to force yourself into a rigid day-by-day format that puts your time in a box. Instead you can do whatever you want on the page, with the helpful guidance of the little circle of time in the middle of each page.

While the Chronodex has been designed for you and is ready-to-print, there is some assembly required. Binding it all together doesn't require much more than a few staples, but the full post over at Scription offers suggestions and instructions for making a much more beautiful end product. If you're looking for a better way to plan 2012, go check it out.

Scription Chronodex Weekly Planner 2012 - free download with the cost of a prayer | Scription

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/YP62q49V4gQ/scription-chronodox-is-a-beautiful-printable-freeform-weekly-planner-for-the-new-year

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Bleakest outlook takes prize for forecasting

By Martin Wolk

For msnbc.com's panel of economic forecasters, the most pessimistic were the most accurate this year as the economy failed to meet even the relatively modest expectations of most experts.

David Rosenberg, the Canadian economist frequently known for his bearish views, takes the prize this year for the closest forecast among the 12 economists on our panel.

Gluskin Sheff

David Rosenberg says "retirement will become an increasingly elusive dream for many."

Rosenberg, chief economist for Gluskin Sheff & Associates, a wealth management firm, wins honors mainly because he correctly anticipated a year ago that 2011 would be a year of slow growth. Rosenberg projected U.S. economic growth of 2.3 percent for this year, compared with current projections that put GDP growth at just 1.7 percent for the year.

Rosenberg sees plenty of peril in the year ahead, especially with Europe in the midst of what he describes as a recession and China coming down from a heady period of rapid growth.

"2012 is probably going to be even more of a challenging year than 2011," he said.

While industrial companies have been driving the weak economic recovery for the past two years, they will be pressured this year by the strengthening dollar and the weakening of their primary markets in Asia and Europe, he said.

The expected expiration of Bush-era tax cuts at the end of 2012 also will cause anxiety and dampen consumer spending as Americans boost their personal savings in anticipation of lower take-home pay, he said.

While the labor market is "healing," most of the growth is in low-wage industries such as retail and hospitality, while high-paying industries such as?manufacturing and finance are laying off workers, Rosenberg said. As for housing, sales activity has picked up but prices are still declining, which has a negative impact on consumer confidence and perceptions of wealth.

Rosenberg just barely beat UCLA's Ed Leamer, another frequently bearish forecaster. Our methodology looked at how accurately forecasters predicted overall economic growth, consumer inflation, unemployment and short-term interest rates.

Most panelists, including Rosenberg, were overly pessimistic about the employment market, which has been weak but not?quite as bad as some had feared. Most economists predicted the unemployment rate would remain above 9 percent for the full year, but a sharp drop last month puts the current rate at 8.6 percent.

Most economists on our panel badly underestimated inflation, predicting consumer prices would rise less than 1 percent in 2011, compared with the actual 2.2 percent rate, excluding volatile food and energy prices.

Most economists predicted correctly that the Federal Reserve would leave interest rates at their current level of about zero percent, which the central bank has now virtually promised to leave in place through at least mid-2013.

With this ninth edition of our annual economic roundtable we are suspending the feature, although we continue to turn to our experts frequently for their regular analysis of the economy.

This year, for a change, we are turning to a different kind of expert and asking small business owners what they think about the prospects for the economy. We will be checking back with them often for their views on the economy.

?

Source: http://bottomline.msnbc.msn.com/_news/2011/12/28/9642067-bleakest-outlook-takes-prize-for-forecasting

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Thursday, December 29, 2011

NKoreans salute, cry for late leader Kim Jong Il (AP)

PYONGYANG, North Korea ? North Korea's next leader escorted his father's hearse in an elaborate state funeral on a bitter, snowy day Wednesday, bowing and saluting in front of tens of thousands of citizens who wailed and stamped their feet in grief for Kim Jong Il.

Son and successor Kim Jong Un was head mourner on the gray day in Pyongyang, walking with one hand on the black hearse that carried his father's coffin on its roof, his other hand raised in salute, his head bowed against the wind.

At the end of the 2 1/2-hour procession, rifles fired 21 times as Kim Jong Un stood flanked by the top party and military officials who are expected to be his inner circle of advisers. Kim then saluted again as goose-stepping soldiers carrying flags and rifles marched by.

Although analysts say Kim Jong Un is on the path toward cementing his power and all moves in North Korea so far ? from titles giving him power over the ruling party and military and his leading position in the funeral procession ? point in that direction, his age and inexperience leave questions about Kim's long-term prospects. Whereas his father was groomed for power for 20 years before taking over, the younger Kim has had only about two years.

He also faces the huge challenges of running a country that struggles to feed its people even as it pursues a nuclear weapons program that has earned it international sanctions and condemnation.

Kim Jong Il ? who led with absolute power after his father Kim Il Sung's death in 1994, through a famine that killed hundreds of thousands and the pursuit of nuclear and missile programs ? died of a heart attack Dec. 17 at age 69.

Mourners in parkas lined the streets of Pyongyang, waving, stamping and crying as the convoy bearing his coffin passed. Some struggled to get past security personnel holding back the crowd.

"How can the sky not cry?" a weeping soldier standing in the snow said to state TV. "The people ... are all crying tears of blood."

The dramatic scenes of grief showed how effectively North Korea built a personality cult around Kim Jong Il despite chronic food shortages and decades of economic hardship.

A large challenge for North Korea's propaganda apparatus will be "to counter the public's perception that the new leader is a spoiled child of privilege," said Brian Myers, an expert on North Korean propaganda at Dongseo University in Busan, South Korea.

"Having Kim Jong Un trudge mournfully next to the hearse in terrible weather was a very clever move," Myers said.

Even as North Koreans mourned the loss of the second leader the nation has known, the transition of power to Kim Jong Un was well under way. The young man, who is in his late 20s, is already being hailed by state media as the "supreme leader" of the party, state and army.

Kim wore a long, dark overcoat as he strode alongside his father's hearse accompanied by top party officials behind him and key military leaders on the other side of the limousine ? a lineup that was a good look at who will be the core leadership in North Korea.

North Korea now turns to Thursday's memorial ceremony. Although there will be tributes to Kim Jong Il, the country will be turning toward Kim Jong Un, analysts said.

"The message will be clear: Kim Jong Un now leads the country and there is no alternative," said Kim Yeon-su, a North Korea expert at the state-run Korea National Defense University in South Korea.

There will also be more attention paid to the inner circle forming around Kim Jong Un.

On Wednesday, he was accompanied by Jang Song Thaek, Kim Jong Il's brother-in-law and a vice chairman of the powerful National Defense Commission, who is expected to be crucial in helping Kim Jong Un take power.

Also escorting the limousine were military chief Ri Yong Ho and People's Armed Forces Minster Kim Yong Chun. Their presence indicates they will be important players as the younger Kim consolidates his leadership. Top Workers' Party officials Choe Thae Bok and Kim Ki Nam and senior military officer Kim Jong Gak also took prominent positions.

The early part of Wednesday's funeral ceremony was shrouded in secrecy, as in 1994, when Kim Il Sung died. Back then, Kim Jong Il and top officials held a private, hourlong ceremony inside the Kumsusan palace before the procession through the city, according to his official biography.

Pyongyang's foreign diplomats were invited to attend the procession, though few other outsiders appeared to be allowed into the country for the funeral. One foreign diplomat in Pyongyang, who asked not to be named because of the sensitive nature of her work, said funereal music played and people wept as the convoy left Kumsusan followed by a large number of vehicles and army jeeps.

After showing taped footage of mourners and documentaries of Kim Jong Il, state TV began airing the procession, showing cars moving slowly through the snowy city, led by a limousine carrying a huge portrait of a smiling Kim Jong Il.

Wednesday's procession had a stronger military presence than 1994.

Kim Jong Il, who ushered in a "military first" era when he took power, celebrated major occasions with lavish, meticulously choreographed parades designed to show off the nation's military might, such as the October 2010 display when he introduced his son to the world.

Kim Jong Un was made a four-star general and appointed a vice chairman of the Central Military Commission of the ruling Workers' Party last year.

After the funeral, the young Kim is expected to solidify his power by formally assuming command of the 1.2 million-strong military, and becoming general secretary of the Workers' Party and chairman of the party's Central Military Commission, said Yoo Ho-yeol, a professor at Korea University in South Korea.

Kim Jong Il's two other sons, Kim Jong Nam and Kim Jong Chol, were not spotted at the procession.

___

Associated Press Korea bureau chief Jean H. Lee and writers Hyung-jin Kim, Foster Klug, Scott McDonald and Sam Kim in Seoul, South Korea, contributed to this report. Follow AP's North Korea coverage at twitter.com/newsjean, twitter.com/APKlug and twitter.com/samkim_ap.

Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/ap/20111228/ap_on_re_as/as_kim_jong_il_the_funeral

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Former New Mexico Governor to run for president as Libertarian

By The Associated Press

Former New Mexico Gov. Gary Johnson, a longshot candidate for the Republican presidential nomination, said Wednesday he is leaving the GOP in favor of running as a Libertarian.

Johnson told a news conference at the state Capitol that the decision was difficult, but that he was "deeply disappointed" by the treatment he received in the Republican nomination process.

"I had hoped to lay out a real libertarian message on all the issues in the Republican contest. The process was not fair and open," he said.

Johnson has been excluded from all but two GOP presidential debates. He also has barely registered in the polls.

The former two-term governor said that if he earns the Libertarian Party's presidential nomination, he will appear on the ballots in all 50 states and will not be "held hostage to a system rigged for the wealthiest and best-known candidates in a handful of states who happen to have early primaries."

Johnson is fiscally conservative but supports legalizing marijuana and abortion rights.

He laid out an agenda that also includes ending deficit spending and cutting federal spending by 43 percent. He called for ending gun control, ending expensive foreign wars, cutting over-regulation and legalizing gay marriage.

"I believe this election needs a true libertarian voice," he said. "While Ron Paul is a good man and a libertarian who I proudly endorsed for president in 2008, there is no guarantee that he will be the Republican nominee."

Source: http://feedproxy.google.com/~r/tbo/nationworld/~3/pw6tSlvc6Dk/

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Wednesday, December 28, 2011

Kris Humphries Held to Six Rebounds in Blowout Loss


Kris Humphries and the New Jersey Nets made their home debut against the Atlanta Hawks last night, and Kim Kardashian's ex was greeted with loud applause from the sellout crowd.

But he and his teammates gave the crowd little to cheer about after the opening buzzer.

The Hawks blew the Nets off the floor, winning by a final of 106-70 - quite the contrast for New Jersey from the night before - and holding last year's fifth-leading NBA rebounder to just six boards. Granted, he sat out most of the second half.

Through two games, Humphries' stats look like this:

Updated Kris Stats

Source: http://www.thehollywoodgossip.com/2011/12/kris-humphries-held-to-six-rebounds-in-blowout-loss/

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Swedish reporters sentenced to 11 yrs in Ethiopia (AP)

ADDIS ABABA, Ethiopia ? A court in Ethiopia has sentenced two Swedish journalists to 11 years in prison.

The two freelance reporters ? Johan Persson and Martin Schibbye ? were found guilty by a court last week of supporting terrorism after the pair illegally entered the country with an ethnic Somali rebel group.

Judge Shemsu Sirgaga ruled Tuesday that the two should be sentenced to 11 years each of "rigorous imprisonment."

Ethiopian troops captured Persson and Schibbye six months ago during a clash with rebels in eastern Ethiopia's restive Somali region, a no-go area for reporters. Ethiopia considers the rebel group a terrorist organization, and it is very difficult for journalists to gain access to the region. Rights groups say that is so abuses there are not exposed.

Source: http://us.rd.yahoo.com/dailynews/rss/africa/*http%3A//news.yahoo.com/s/ap/20111227/ap_on_re_af/af_ethiopia_journalists

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Tuesday, December 27, 2011

Cuba wraps up dramatic year of economic change (AP)

HAVANA ? A year at the vanguard of Cuba's economic revival has not brought Julio Cesar Hidalgo riches. The fledgling pizzeria owner has had his good months, but the restaurant he opened with his girlfriend often runs at a loss. At times, they can't afford to buy basic ingredients.

Yet the wide-faced 31-year-old says he is grateful to be in business at all. A year ago, Hidalgo was concocting chalky pastries in a Spartan state-run bakery where employees and managers competed to pilfer eggs, flour and olive oil, the only way to make ends meet on salaries of just $15 a month. Today, he is his own boss, a taxpayer, employer and entrepreneur.

"I think my expectations were met because in Cuba today I couldn't have hoped for anything more," he said one recent December afternoon as his girlfriend, Giselle de la Noval, served customers. "We survived."

Hidalgo's story is mirrored by many of the entrepreneurs The Associated Press has followed since January in a yearlong effort to document Communist Cuba's awkward embrace of free-market reforms.

Their experiences ? like the reforms themselves ? cannot be described as an unmitigated success. Of the dozen fledgling business owners, including restaurateurs, a DVD salesman, two cafe owners, a seamstress, a manicurist and a gymnasium operator, three have closed down or begun working for someone else, and one has been harassed by her former state employers. None could be considered successful by non-Cuban standards.

But despite their struggles, many tell of lives transformed, dreams realized, attitudes changed, and doors opened that had been closed for more than half a century.

For Hidalgo, personal hardships have added to the challenges of starting a business on a Marxist island that has looked askance at entrepreneurship since Fidel Castro's 1959 revolution turned a one-time capitalist playground into a Soviet satellite.

After suffering through a slow, hot, summer when nobody wanted a pizza, Hidalgo had to close for two months to care for his grandmother, who has Alzheimer's disease. Even while the business was shuttered, he and de la Noval had to make tax and social security payments, wiping out the few hundred dollars they had saved.

They reopened in late November with so little money they can't always afford to serve their house special.

"We've had to start from scratch, but the only reason we didn't lose the business altogether is because we were disciplined," said de la Noval, 23. "Before we did anything, we always put away the money we needed to pay the state."

A year that President Raul Castro described as make or break for the revolution is ending after a dramatic flurry of once-unthinkable reforms that are transforming economic and social life.

In October, the government legalized a used car market, and a month later extended it to real estate, sweeping away decades of prohibitions. On Tuesday, the state began extending bank credits to new business owners and those hoping to repair their homes.

But one of the most powerful reforms was Castro's decision last year to greatly expand the ranks of the self-employed, part of a somewhat unsuccessful effort to trim bloated state-payrolls.

Some 338,000 people have received licenses to start their own businesses, and the results can be seen and heard everywhere. On nearly every street in Havana and in thousands of hamlets and towns across Cuba, makeshift signs and bright parasols mark the entrances of new businesses, and the long-lost cries of curbside vendors hawking everything from fruit and vegetables to mops and household repair services fill the warm Caribbean air.

"The reforms have advanced, perhaps not quickly enough considering the problems that have accumulated, but they have advanced, one after another, and there is no sign that they will stop or be rolled back," said Omar Everleny Perez, the head of Havana University's Center for Cuban Economic Studies

The government has declined to release any statistics on tax revenue or payroll savings from the reforms, except for an October report in the Communist Party newspaper Granma that said tax revenue from new businesses had tripled.

Cuban leaders this month lowered their forecast for economic growth for 2011 to just 2.7 percent ? from the 3 percent originally hoped for ? an extremely poor showing for a developing country. By contrast, China is forecast to grow by about 9 percent in 2011, Vietnam by between 6 and 6.5 percent and Brazil by 3.8 percent.

Private business owners have complained about the high taxes they must pay, the lack of raw materials and the fact they are suddenly surrounded by competitors. Because most entrepreneurs don't have the capital to start innovative businesses, many have opened cafeterias, nail parlors, small roadside kiosks and the like.

Anisia Cardenas, a seamstress, is among more than 100,000 Cubans who have held private business licenses since the 1990s, the island's last experiment with the free market. In the latest reform, she decided to expand, paying $2 a day to rent the front porch space of a neighbor's house to set up her sewing machine.

But business was slow ? and competition from new license holders fierce. Within a few months she had to retreat to her tiny apartment. By the summer, she began to wonder if she might have to close down, unable to meet the $19 monthly tax payments. By December, she had gone to work as an employee for another seamstress.

"Things are hard," said Cardenas, who is trying to save money for her daughter's 15th birthday party in January. "Everything is very expensive."

Others complain of rules that are often illogical, and state employers who still view entrepreneurship with suspicion.

Maria Regla Saldivar is a black belt in taekwondo who got a license to give private lessons to neighborhood kids in a scruffy park across the street from her job. She began the year with dreams of persuading the government to let her turn an abandoned dry-cleaning warehouse into a private recreation center.

But the government refused to grant her a lease. Then her bosses at Cuba's National Sports Institute docked her pay because they said her outside work was affecting her performance. She quit. Finally, her former boss prohibited her from using the park for martial arts lessons, which are technically prohibited. The government considers it potentially deadly training, even though most of Saldivar's students are not even teenagers yet.

"It's called envy," Saldivar said of her boss.

She insists she is not teaching taekwondo, slyly calling the discipline "Quimbumbia" ? a word of her own invention. She has moved classes for her 14 students into the tiny covered patio in the back of the apartment she shares with her teenage daughter.

But Saldivar says she has no regrets about how the year has unfolded. She says making business decisions for herself has increased her self-esteem, and she is thrilled that she's managed to put away 2,000 pesos ($80), about four months salary at an average state job.

"You may laugh, but for me it's a lot of money," she said, running her coarse fingers over the stripes on a pair of sky-blue track suit bottoms she bought. "I've wanted these for so long and now I have them. I look like a proper trainer now, not someone out picking mangoes from a tree."

Rafael Romeu, the head of the Washington, D.C.-based Association for the Study of the Cuban Economy, said Castro has "changed the conversation" since taking over from his ailing brother in 2006, pushing the leadership to get the island's economic house in order rather than blaming external factors like the 49-year U.S. travel and trade embargo.

But so far, the changes don't go far enough to revive Cuba's moribund economy.

"These are positive steps but when you say them out loud, just think about it ... You are allowed to have a cell phone, you are allowed to buy a home, you are allowed to buy a car or have a microenterprise. This is not the fall of the Berlin Wall. These are not major changes," he said. "Cuba has tremendous difficulties. This is a marathon, and they are taking baby steps."

Romeu, who has worked around the world studying emerging economies, said that Cuba is moving much more deliberately than the Chinese did when they began opening their economy in the late 1970s, or the Vietnamese a decade later.

Cuba's predicament is somewhat different, as well. Both China and Vietnam were deeply agrarian economies whose challenge was lifting tens of millions out of crushing poverty, Romeu said. Cuba is a more urban country with an aging population whose citizens have gotten used to benefits like health care and education, but who have grown accustomed to a system that doesn't make them work for such middle class perks.

"In Cuba, the challenge is sustaining the middle class, not creating one," Romeu said.

Still, some reforms seem to be moving along more quickly than many analysts had hoped.

Business is booming at a street corner long known as the center of Havana's informal real estate market. Only now, the handwritten listings on trees openly advertise legal home sales, instead of disguising them as property "swaps."

Mendez Rodriguez, an unofficial real estate broker, said the buying and selling is aboveboard, controlled by a relatively untangled bureaucracy.

"Everything is by the law now," said Rodriguez, even if his profession is not officially licensed. He and other so-called facilitators work for "gifts" left to the discretion of their clients, he said.

Rumors that real estate brokers would be the latest addition to the list of 181 licensed entrepreneurial activities have not come to pass, but there's still hope the profession will be added in 2012. Rodriguez said the opening seems to have led to a steep increase in prices, with a home worth $20,000 a couple of months ago going for 50 percent more today.

That's the kind of price jump many of the new struggling business owners say they could use.

Javier Acosta has sunk more than $30,000 he saved as a waiter into his own upscale establishment, and says business is far from booming.

"This has been a hard year, a year of sacrifice," he said. "There are days when nobody comes, or when I have just one or two tables, and then there are days when the place is filled."

He said his costs run to about $1,000 a month, and when business is slow he struggles to break even.

Yet the reforms, he says, have changed the face of Cuba, and cynical countrymen who doubt the opening will be lasting must wake up to a new reality.

"After 50 years where everything was prohibited it takes time to change people's minds and make them understand that this time is different," he said, sitting in his empty second-floor restaurant one recent afternoon. "If you don't work, you don't eat."

Despite his struggles, Acosta says he would take the risk again if given the chance, a sentiment shared by Hidalgo and de la Noval. They had hoped to close on New Year's Eve, which Cubans of means celebrate with a traditional feast of pork leg, yucca, black beans and sweets.

Hidalgo said the family simply doesn't have enough saved to take the night off after its year of trials and tribulations. Instead, he's planning to keep the pizzeria open late and celebrate on the job with his girlfriend and his aunt at his side.

"We're thinking of making a small meal for the three of us," he said. "If we can afford a leg of pork it'll be to sell, not to eat ourselves."

___

Associated Press writers Peter Orsi, Andrea Rodriguez and Anne-Marie Garcia contributed to this report.

___

Paul Haven can be reached at http://www.twitter.com/paulhaven/

Source: http://us.rd.yahoo.com/dailynews/rss/latam/*http%3A//news.yahoo.com/s/ap/20111225/ap_on_re_la_am_ca/cb_cuba_s_year_of_change

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Deputy of Pentecostal Union: Revolution is not a way for Russia

ASSIST News Service (ANS) - PO Box 609, Lake Forest, CA 92609-0609 USA
Visit our web site at: www.assistnews.net -- E-mail: assistnews@aol.com


Friday, December 23, 2011

Deputy of Pentecostal Union: Revolution is not a way for Russia

By Victoria Uzunova of the Christian Telegraph (www.christiantelegraph.com)
Special to ASSIST News Service

MOSCOW, RUSSIA (ANS) -- Konstantin Bendas, the First Deputy of the Supervisory Bishop of the Associated Russian Union of Christians of Evangelical-Pentecostal Faith, has said that revolution is "not a way for Russia."

A woman with with a child casts her ballot next to a young Russian cossak (R) at a polling station during the parliamentary election in the southern Russian city of Rostov-on-Don December 4, 2011.
(Vladimir Konstantinov/Reuters)

He commented on the political situation in Russia after the recent parliamentary elections, during?which, in light of the persistent protests and objections to the fact that the controversial United Russia party won nearly 50% of the votes, many priests and spiritual leaders have been asked about the role of the church in political turmoil.

Mr. Bendas believes that these inquiries are good since priests ?should find answers and true and sincere words for those who trust him.?

Konstantin Bendas added that ?one can only rejoice that the church still remains an authoritative institution in our secular society.? He also noted that a lot of journalists sought definitive answers regarding whom the church supported.

?We don?t have a definitive answer or a solution to this situation. People who urge for riots, revolution and violent upheaval are wrong, but those who falsify the truth and the elections results are also wrong,? underlined the First Deputy.

Konstantin Bendas
(Photo via www.invictory.org)

?Our position, as a religious organization, is to pray and abstain from unlawful acts and support those who demand protection of their civil rights. We don?t need confrontation in our society, but it is necessary for us to have a constructive work for the defense of human rights. We believe that it would me more effective to file an action to a public prosecutor's office, police offices and committees of inquiry.

?And where the rights of voters were encroached upon, justice must be obtained. The results must be recounted and guilty must be punished according to the law,? underlined Bendas.

?We want to emphasize that revolution is not a proper way for Russia. The Church should call for reformation as a return to moral and spiritual values that are stipulated in the Bible,? concluded the minister.



Victoria Uzunova is a correspondent for the Christian Telegraph [www.christiantelegraph.com], a unique Christian news service partnering with the largest Christian News Agency in Russian language InVictory News [www.invictory.org/news/] which is one of few news gateways of what is happening in Christianity in such former USSR countries as Russia, Ukraine, Belarus, Latvia, Lithuania, Estonia, Kazakhstan, Uzbekistan, Turkmenistan, Kyrgyzstan, Armenia, Georgia and others.

?


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Source: http://www.assistnews.net/Stories/2011/s11120104.htm

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Monday, December 26, 2011

A Christmas Miracle! Facebook Chat (Kind Of) Supports Extended Rage Faces

00yQjFirst, if you want to get right down to it, here are the codes you type into Facebook chat to get various faces:
Poker face [[129627277060203]] Forever Alone [[227644903931785]] OK guy [[100002752520227]] Me Gusta [[164413893600463]] Lol guy [[189637151067601]] Fuck Yeah [[105387672833401]] Problem? [[171108522930776]] [[218595638164996]] [[100002727365206]]
Huzzah! We are truly living in an age of wonder! Second, why does this work?

Source: http://feedproxy.google.com/~r/Techcrunch/~3/4vjfscY0fsI/

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Source: http://nl.hardware.info/extern/21543888/kein-android-4-fur-das-galaxy-s-a-tab

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Sunday, December 25, 2011

Minn. Church Recalls How Christmas Carols Saved Some U.S. Lives in World War II

RAY SUAREZ: Finally tonight, the true tale of a Christmas Eve attack and rescue during World War II, retold by a Minnesota congregation.

Special correspondent Fred de Sam Lazaro has our story.

FRED DE SAM LAZARO: At the annual holiday dinner at Westminster Presbyterian Church in Minneapolis, people are encouraged to share personal Christmas stories.

This year, Pastor Tim Hart-Andersen delivered an epic.

REV. TIM HART-ANDERSEN, Westminster Presbyterian Church: So you are a radio studio audience tonight for WPCB, Westminster Presbyterian Church Broadcast Company.

(LAUGHTER)

FRED DE SAM LAZARO: Dozens of volunteers came together to build a set simulating a 1940s-style radio drama, arranged by "Prairie Home Companion" veteran and church member Vern Sutton.

It's based on a true story the pastor heard from his father when he was growing up.

MAN: The night before Christmas, 1944.

FRED DE SAM LAZARO: On Dec. 24, 1944, as the decisive Battle of the Bulge raged, some 2,200 American G.I.s boarded the ship Leopoldville in England headed for the battle's Belgian frontier.

MAN: It just don't feel like Christmas Eve.

FRED DE SAM LAZARO: Hart-Andersen's father, Hank Andersen, was crammed in the ship's hold.

REV. HENRY "HANK" ANDERSEN, Leopoldville survivor: It was just a miserable situation. So I said, let's go up on deck and sing Christmas carols. I would say there were 15 to 20 of us were there.

And we were singing Christmas carols. And I was leading them. And all of a sudden, this is becoming a rather tender story. And we can see the lights of Cherbourg in the distance.

FRED DE SAM LAZARO: The drama used sound effects to convey the disaster that was about to strike as the ship was just off the French coast. Some 800 lives were lost in the deadliest incident of the war for the U.S. Army.

WOMAN: Emergency stations. Emergency stations. All hands to emergency stations. The Leopold's been hit.

WOMAN: The U-boat torpedo hits the Leopoldville below the waterline on the starboard side. Scores of those lovely Yankee boys are killed instantly by the explosion. Others drown as water rushes into the ship. Most of the survivors stand on the deck and watch as other ships come alongside to begin rescue operations.

MAN: Hey, Sarge, Sarge, Sarge, what do we do? That British destroyer, it's pulled up alongside us. Shall we make a jump for it?

REV. HENRY "HANK" ANDERSEN: These guys were paralyzed. They just would not jump. And -- and they had seen some jump and not made it. So, it was quite a jump across.

And I remember getting over there and sliding across what little deck there was, slammed into the bulwark that was there, staggered back up to the rail. And the sight that I had made it enabled them then to start jumping.

MAN: Gee, Rosenblum, are you going to jump?

MAN: Is there another choice?

FRED DE SAM LAZARO: The character Rosenblum was written into the drama when Gail Rosenblum, a local columnist, came across Andersen's story. Her late father, Sidney, was on the ship, and she's convinced he was in the singing group. And that, she'd like to think, influenced her love of this music.

GAIL ROSENBLUM, Minneapolis Star Tribune: My friends joke. They tease me because I'm a Jewish girl who loves Christmas carols. I always loved them as a girl.

And so, when I heard the story of Hank and put that all together, I felt like now I understand why I love them. They saved my father's life, because all the men who came up on deck to sing, thanks to Hank leading them up there, they survived. And all the men who didn't come up were the victims of that, you know, that torpedo.

REV. TIM HART-ANDERSEN: Her father had this love of music before he went into the service. My father did. And the more we talked, the more we began to sense a kind of narrative that really wound together in some pretty remarkable ways.

MAN: Hey, Archer, can't a Jew enjoy the lights and sing a few tunes?

MAN: You sing Christmas music?

MAN: So, who do you think does the best Christmas music? Ever wonder about that? Irving Berlin? Mel Torme? Johnny Marks? All Jews. "Winter Wonderland," "White Christmas" all invented by my people. Who else would name a red-nosed reindeer Rudolph?

(LAUGHTER)

FRED DE SAM LAZARO: His family says Sid Rosenblum talked very little about his war experience. He went on to become a psychologist. Sid Rosenblum died in 1988 at 63.

Hank Andersen was headed to a law career before the war, but became a minister instead. He was an active civil rights campaigner in the '60s, influenced during the war by an all-black unit in the then-segregated Army which fed and comforted the ship's survivors when they reached land.

REV. HENRY "HANK" ANDERSEN: They surrounded us and sang Christmas carols. And I -- I was so stunned.

FRED DE SAM LAZARO: At 87, Hank Andersen lives in retirement with Mary Andersen, his wife of 64 years.

MAN: The Yanks who survived found a whole new meaning to that Christmas day.

FRED DE SAM LAZARO: Tim Hart-Andersen says he's glad his father is still alive to see an important story preserved by and for the next generation, one that, in some ways, has morphed into a sermon.

REV. TIM HART-ANDERSEN: I would hope that the kind of universal theme here is that hope cannot be cut off and light cannot be turned off. The human spirit can sing its way through anything.

RAY SUAREZ: Fred's reporting is a partnership with the Under-Told Stories Project at Saint Mary's University of Minnesota.

SUPPORT YOUR PBS LOCAL STATION

Source: http://feeds.pbs.org/~r/pbs/newshour-headlines/~3/rQXZkVhhIYY/christmas_12-23.html

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Saturday, December 24, 2011

Sony Pictures Classics Picks Up Woody Allen's Next Film

sony-pictures-classics-woody-allen

After one brief fling in 1999 with Sweet and Lowdown, Sony Pictures Classics got back in the Woody Allen business in 2009 to produce Whatever Works, You Will Meet a Tall Dark Stranger, and Midnight in Paris.? The partnership was especially lucrative this year, since Midnight Paris grossed $144 million worldwide on the way to major Oscar buzz.? So it comes as no surprise when SPC announced today their acquisition of Allen?s next project, Nero Fiddled.? Said Allen:

?[Sony Pictures Classics] seems to be very sensitive to the kind of films I make, and I?m looking forward to working with them now again.?

Set in Rome, Nero Fiddled is comprised of four vignettes?two center on American characters; the other two center on Italians.? Allen will step in front of the camera for the first time since 2006?s Scoop to take on a starring role alongside Alec Baldwin, Roberto Benigni, Pen?lope Cruz, Judy Davis, Jesse Eisenberg, Greta Gerwig, and Ellen Page.? The comedy is tentatively scheduled for a summer 2012 release.? Read the press release after the jump.

SONY PICTURES CLASSICS ACQUIRES WOODY ALLEN?S NERO FIDDLED

Film marks fifth collaboration with the filmmaker and Sony Classics

NEW YORK (December 21, 2011) ? Sony Pictures Classics announced today that they have acquired all North American and UK rights to Woody Allen?s next film, NERO FIDDLED. The film stars Alec Baldwin, Roberto Benigni, Penelope Cruz, Jesse Eisenberg, Greta Gerwig and Ellen Page.

Produced by Letty Aronson, Steve Tenenbaum, Giampaulo Letta and Faruk Alatan, NERO FIDDLED, is a Medusa film and Gravier production. ?The film was Allen?s first film shot in Rome.

NERO FIDDLED marks Allen?s fifth film with Sony Pictures Classics.?Allen?s most recent film with SPC, MIDNIGHT IN PARIS, has made almost $60 million at the box office and is Allen?s highest grossing film in North America. The film also recently garnered four Golden Globe nominations.?SPC?s previous collaborations with Allen include YOU WILL MEET A TALL DARK STRANGER starring Anthony Hopkins, Naomi Watts, Josh Brolin and Frieda Pinto; the 2009 Tribeca Film Festival?s opening night film WHATEVER WORKS starring Larry David, Patricia Clarkson and Evan Rachel Wood; and SWEET AND LOWDOWN, which garnered Oscar nominations for Sean Penn and Samantha Morton.

?More laughs in this one than you can imagine. We know it?s a bit premature, but thank you Woody and company, for granting us the perfect summer comedy of 2012. Keep ?em coming,? says Sony Pictures Classics.

Allen adds, ?I?ve had a number of very good experiences working with Sony Classics, culminating most recently with MIDNIGHT IN PARIS. They seem to be very sensitive to the kind of films I make, and I?m looking forward to working with them now again.?

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Source: http://www.rottentomatoes.com/m/1924196/news/1924196/

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NBA roundup: Spurs slip past Rockets

ASSOCIATED PRESS

? Tim Duncan scored 19 points and Tony Parker added 15 to help the San Antonio Spurs hold off the Houston Rockets for a 97-95 preseason win on Wednesday night.

Jeremy Lin's driving layup capped a 10-0 run that tied it 95-all with 34.6 seconds left, but rookie Kawhi Leonard hit a 20-footer from the left wing to give the Spurs the win.

Reserve Marcus Morris scored 20 points, and Chase Budinger and Kyle Lowry each added 10 for Houston.

Duncan's block of Lowry combined with a pretty bounce pass on a James Anderson layup sparked a 6-0 run to break a 70-70 third-quarter tie.

Duncan and Parker returned to the starting lineup after sitting out Saturday's preseason opener against the Rockets in Houston.

Parker scored 11 of his 15 points in the first quarter to lead the Spurs to a 14-4 lead before the Rockets made a run to close the quarter down by six.

Houston's second-unit led by Morris put the Rockets up 53-51 at the half.

Orlando 104, Miami 100: Glen Davis had 18 points, Dwight Howard and Jason Richardson each added 15 and the Magic overcame a 14-point halftime deficit to beat the Heat.

LeBron James had 27 points and Dwyane Wade added 21 for the Heat. Reserve Norris Cole chipped in 11 points.

Minnesota 85, Milwaukee 84: Michael Beasley made two free throws with 9.1 seconds left to lift the Timberwolves over the Bucks. Kevin Love, who had 22 points and 16 rebounds, hit a 3-pointer to cut Milwaukee's lead to 84-83. Luke Ridnour intercepted Larry Sanders' poor inbound pass on the next possession and Beasley did the rest for Minnesota, which overcame a 10-point deficit.

New Orleans 95, Memphis 80: Chris Kaman scored 18 points and Eric Gordon added 17 in their first game with New Orleans, leading the Hornets over the Grizzlies

Boston 81, Toronto 73: Rajon Rondo scored 15 of his 17 points in the first half, leading the Boston Celtics to an 81-73 victory over Toronto on Wednesday night and a sweep of their two-game preseason series with the Raptors.

New York 88, New Jersey 82: Carmelo Anthony had 21 points and eight rebounds, and the Knicks tuned up for the NBA season opener by beating the Nets.

Golden State's Ellis accused of sexual harassment

OAKLAND, Calif. ? A former Golden State Warriors employee filed a sexual harassment lawsuit against star guard Monta Ellis on Wednesday, alleging Ellis sent her unwanted texts that included a photo of his genitals.

In her lawsuit, which also names the team, Erika Ross Smith alleges Ellis began sending her several dozen explicit messages, sometimes several times a day, starting in November 2010 while she worked for the team's community relations department.

The messages included lines such as, "I want to be with you," and "Hey Sexy," and periodically asked her what she was wearing or doing, according to the lawsuit.

Smith would often reply with "What do you want?" or "I am sleeping," the lawsuit claims.

Ellis' agent, Jeffrey Fried, said Wednesday that he was en route to Oakland and didn't immediately have a comment.

According to the lawsuit, the Warriors changed Smith's job description and eventually fired her after Ellis' wife, Juanika Ellis, learned of the texts and complained to team executives in January.

Bryant has torn wrist ligament

LOS ANGELES ? Kobe Bryant did not play in the Los Angeles Lakers' preseason finale against the Clippers on Wednesday night because of a torn ligament in his right wrist. His status for the season opener on Christmas Day is up in the air.

Source: http://www.statesman.com/sports/nba-roundup-spurs-slip-past-rockets-2046787.html?cxtype=rss_sports

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Friday, December 23, 2011

And the Grammy goes to ? Steve Jobs!

First it was a bronze statue in Hungary. Now it?s a Grammy.

The accolades for the technology icon who died?Oct 5 are still pouring in.

While Jobs is not a musician, his influence on the music industry ? good or bad ? cannot be denied. And for this, the National Academy of Recording Arts and Sciences is giving the co-founder of Apple Inc a Grammy at an invitation-only ceremony on Feb 11.

A formal acknowledgment of his Grammy ? part of the 2012 Special Merit Award ? will be made during the regular 54th annual Grammy Awards, to be held on Feb 12 at LA?s Staples Center.

?As former CEO and co-founder of Apple, Steve Jobs helped create products and technology that transformed the way we consume music, TV, movies, and books,? the academy said in a statement. ??A creative visionary, Jobs? innovations such as the iPod and its counterpart, the online iTunes store, revolutionized the industry and how music was distributed and purchased.?

In 2002, Apple was a recipient of a technical Grammy award for contributions of outstanding technical significance to the recording field.

Honored alongside Jobs?were other industry luminaries including?musician and composer Dave Bartholomew, and recording engineer Rudy Van Gelder.

Source: http://blogs.reuters.com/mediafile/2011/12/22/and-the-grammy-goes-to-steve-jobs/

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Researcher contends multiple sclerosis is not a disease of the immune system

Researcher contends multiple sclerosis is not a disease of the immune system [ Back to EurekAlert! ] Public release date: 22-Dec-2011
[ | E-mail | Share Share ]

Contact: Kevin Stacey
kstacey@press.uchicago.edu
401-284-3878
University of Chicago Press Journals

An article to be published Friday (Dec. 23) in the December 2011 issue of The Quarterly Review of Biology argues that multiple sclerosis, long viewed as primarily an autoimmune disease, is not actually a disease of the immune system. Dr. Angelique Corthals, a forensic anthropologist and professor at the John Jay College of Criminal Justice in New York, suggests instead that MS is caused by faulty lipid metabolism, in many ways more similar to coronary atherosclerosis (hardening of the arteries) than to other autoimmune diseases.

Framing MS as a metabolic disorder helps to explain many puzzling aspects of the disease, particularly why it strikes women more than men and why cases are on the rise worldwide, Corthals says. She believes this new framework could help guide researchers toward new treatments and ultimately a cure for the disease.

Multiple sclerosis affects at least 1.3 million people worldwide. Its main characteristic is inflammation followed by scarring of tissue called myelin, which insulates nerve tissue in the brain and spinal cord. Over time, this scarring can lead to profound neurological damage. Medical researchers have theorized that a runaway immune system is at fault, but no one has been able to fully explain what triggers the onset of the disease. Genes, diet, pathogens, and vitamin D deficiency have all been linked to MS, but evidence for these risk factors is inconsistent and even contradictory, frustrating researchers in their search for effective treatment.

"Each time a genetic risk factor has shown a significant increase in MS risk in one population, it has been found to be unimportant in another," Corthals said. "Pathogens like Epstein-Barr virus have been implicated, but there's no explanation for why genetically similar populations with similar pathogen loads have drastically different rates of disease. The search for MS triggers in the context of autoimmunity simply hasn't led to any unifying conclusions about the etiology of the disease."

However, understanding MS as metabolic rather than an autoimmune begins to bring the disease and its causes into focus.

THE LIPID HYPOTHESIS

Corthals believes that the primary cause of MS can be traced to transcription factors in cell nuclei that control the uptake, breakdown, and release of lipids (fats and similar compounds) throughout the body. Disruption of these proteins, known as peroxisome proliferator-activated receptors (PPARs), causes a toxic byproduct of "bad" cholesterol called oxidized LDL to form plaques on the affected tissue. The accumulation of plaque in turn triggers an immune response, which ultimately leads to scarring. This is essentially the same mechanism involved in atherosclerosis, in which PPAR failure causes plaque accumulation, immune response, and scarring in coronary arteries.

"When lipid metabolism fails in the arteries, you get atherosclerosis," Corthals explains. "When it happens in the central nervous system, you get MS. But the underlying etiology is the same."

A major risk factor for disruption of lipid homeostasis is having high LDL cholesterol. So if PPARs are at the root of MS, it would explain why cases of the disease have been on the rise in recent decades. "In general people around the world are increasing their intake of sugars and animal fats, which often leads to high LDL cholesterol," Corthals said. "So we would expect to see higher rates of disease related to lipid metabolismlike heart disease and, in this case, MS." This also explains why statin drugs, which are used to treat high cholesterol, have shown promise as an MS treatment.

The lipid hypothesis also sheds light on the link between MS and vitamin D deficiency. Vitamin D helps to lower LDL cholesterol, so it makes sense that a lack of vitamin D increases the likelihood of the diseaseespecially in the context of a diet high in fats and carbohydrates.

Corthals's framework also explains why MS is more prevalent in women.

"Men and women metabolize fats differently," Corthals said. "In men, PPAR problems are more likely to occur in vascular tissue, which is why atherosclerosis is more prevalent in men. But women metabolize fat differently in relation to their reproductive role. Disruption of lipid metabolism in women is more likely to affect the production of myelin and the central nervous system. In this way, MS is to women what atherosclerosis is to men, while excluding neither sex from developing the other disease."

In addition to high cholesterol, there are several other risk factors for reduced PPAR function, including pathogens like Epstein-Barr virus, trauma that requires massive cell repair, and certain genetic profiles. In many cases, Corthals says, having just one of these risk factors isn't enough to trigger a collapse of lipid metabolism. But more than one risk factor could cause problems. For example, a genetically weakened PPAR system on its own might not cause disease, but combining that with a pathogen or with a poor diet can cause disease. This helps to explain why different MS triggers seem to be important for some people and populations but not others.

"In the context of autoimmunity, the various risk factors for MS are frustratingly incoherent," Corthals said. "But in the context of lipid metabolism, they make perfect sense."

Much more research is necessary to fully understand the role of PPARs in MS, but Corthals hopes that this new understanding of the disease could eventually lead to new treatments and prevention measures.

"This new framework makes a cure for MS closer than ever," Corthals said.

###

Angelique Corthals, "Multiple Sclerosis (MS) is not a disease of the immune system," The Quarterly Review of Biology 86:4 (December 2011).

The premier review journal in biology since 1926, The Quarterly Review of Biology publishes articles in all areas of biology but with a traditional emphasis on evolution, ecology, and organismal biology. QRB papers do not merely summarize a topic, but offer important new ideas, concepts, and syntheses. They often shape the course of future research within a field. In addition, the book review section of the QRB is the most comprehensive in biology.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Researcher contends multiple sclerosis is not a disease of the immune system [ Back to EurekAlert! ] Public release date: 22-Dec-2011
[ | E-mail | Share Share ]

Contact: Kevin Stacey
kstacey@press.uchicago.edu
401-284-3878
University of Chicago Press Journals

An article to be published Friday (Dec. 23) in the December 2011 issue of The Quarterly Review of Biology argues that multiple sclerosis, long viewed as primarily an autoimmune disease, is not actually a disease of the immune system. Dr. Angelique Corthals, a forensic anthropologist and professor at the John Jay College of Criminal Justice in New York, suggests instead that MS is caused by faulty lipid metabolism, in many ways more similar to coronary atherosclerosis (hardening of the arteries) than to other autoimmune diseases.

Framing MS as a metabolic disorder helps to explain many puzzling aspects of the disease, particularly why it strikes women more than men and why cases are on the rise worldwide, Corthals says. She believes this new framework could help guide researchers toward new treatments and ultimately a cure for the disease.

Multiple sclerosis affects at least 1.3 million people worldwide. Its main characteristic is inflammation followed by scarring of tissue called myelin, which insulates nerve tissue in the brain and spinal cord. Over time, this scarring can lead to profound neurological damage. Medical researchers have theorized that a runaway immune system is at fault, but no one has been able to fully explain what triggers the onset of the disease. Genes, diet, pathogens, and vitamin D deficiency have all been linked to MS, but evidence for these risk factors is inconsistent and even contradictory, frustrating researchers in their search for effective treatment.

"Each time a genetic risk factor has shown a significant increase in MS risk in one population, it has been found to be unimportant in another," Corthals said. "Pathogens like Epstein-Barr virus have been implicated, but there's no explanation for why genetically similar populations with similar pathogen loads have drastically different rates of disease. The search for MS triggers in the context of autoimmunity simply hasn't led to any unifying conclusions about the etiology of the disease."

However, understanding MS as metabolic rather than an autoimmune begins to bring the disease and its causes into focus.

THE LIPID HYPOTHESIS

Corthals believes that the primary cause of MS can be traced to transcription factors in cell nuclei that control the uptake, breakdown, and release of lipids (fats and similar compounds) throughout the body. Disruption of these proteins, known as peroxisome proliferator-activated receptors (PPARs), causes a toxic byproduct of "bad" cholesterol called oxidized LDL to form plaques on the affected tissue. The accumulation of plaque in turn triggers an immune response, which ultimately leads to scarring. This is essentially the same mechanism involved in atherosclerosis, in which PPAR failure causes plaque accumulation, immune response, and scarring in coronary arteries.

"When lipid metabolism fails in the arteries, you get atherosclerosis," Corthals explains. "When it happens in the central nervous system, you get MS. But the underlying etiology is the same."

A major risk factor for disruption of lipid homeostasis is having high LDL cholesterol. So if PPARs are at the root of MS, it would explain why cases of the disease have been on the rise in recent decades. "In general people around the world are increasing their intake of sugars and animal fats, which often leads to high LDL cholesterol," Corthals said. "So we would expect to see higher rates of disease related to lipid metabolismlike heart disease and, in this case, MS." This also explains why statin drugs, which are used to treat high cholesterol, have shown promise as an MS treatment.

The lipid hypothesis also sheds light on the link between MS and vitamin D deficiency. Vitamin D helps to lower LDL cholesterol, so it makes sense that a lack of vitamin D increases the likelihood of the diseaseespecially in the context of a diet high in fats and carbohydrates.

Corthals's framework also explains why MS is more prevalent in women.

"Men and women metabolize fats differently," Corthals said. "In men, PPAR problems are more likely to occur in vascular tissue, which is why atherosclerosis is more prevalent in men. But women metabolize fat differently in relation to their reproductive role. Disruption of lipid metabolism in women is more likely to affect the production of myelin and the central nervous system. In this way, MS is to women what atherosclerosis is to men, while excluding neither sex from developing the other disease."

In addition to high cholesterol, there are several other risk factors for reduced PPAR function, including pathogens like Epstein-Barr virus, trauma that requires massive cell repair, and certain genetic profiles. In many cases, Corthals says, having just one of these risk factors isn't enough to trigger a collapse of lipid metabolism. But more than one risk factor could cause problems. For example, a genetically weakened PPAR system on its own might not cause disease, but combining that with a pathogen or with a poor diet can cause disease. This helps to explain why different MS triggers seem to be important for some people and populations but not others.

"In the context of autoimmunity, the various risk factors for MS are frustratingly incoherent," Corthals said. "But in the context of lipid metabolism, they make perfect sense."

Much more research is necessary to fully understand the role of PPARs in MS, but Corthals hopes that this new understanding of the disease could eventually lead to new treatments and prevention measures.

"This new framework makes a cure for MS closer than ever," Corthals said.

###

Angelique Corthals, "Multiple Sclerosis (MS) is not a disease of the immune system," The Quarterly Review of Biology 86:4 (December 2011).

The premier review journal in biology since 1926, The Quarterly Review of Biology publishes articles in all areas of biology but with a traditional emphasis on evolution, ecology, and organismal biology. QRB papers do not merely summarize a topic, but offer important new ideas, concepts, and syntheses. They often shape the course of future research within a field. In addition, the book review section of the QRB is the most comprehensive in biology.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2011-12/uocp-rcm122211.php

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Thursday, December 22, 2011

Most Sick or Disabled Seniors Want Docs to Say How Long They Have (HealthDay)

WEDNESDAY, Dec. 21 (HealthDay News) -- Life expectancy is a topic many disabled seniors want to talk about with their doctors but very few have that discussion, a new study finds.

It included 60 elderly patients with an average age of 78 who had multiple illnesses and disabilities and lived in a community-based, long-term care program in San Francisco. None of the patients had been diagnosed with a specific terminal illness.

Interviews with the patients revealed that 75 percent would want a conversation about their prognosis if their doctor felt they had less than a year to live, while 65 percent would welcome such a dialogue if they likely had fewer than five years to live.

However, only one of the 60 patients reported having such a discussion with a doctor, said the researchers at the San Francisco VA Medical Center and the University of California, San Francisco.

Wanting to prepare for death, making the most of their remaining time and making medical or life decisions were among the most common reasons the patients gave for wanted to discuss their prognosis.

"When physicians bring up prognosis, it's usually thought of as a health issue, but for the person on the receiving end, the conversation is about a lot more than that," lead author Cyrus Ahalt, a geriatrics research coordinator in UCSF's Department of Medicine, said in a university news release.

"We've made big strides in changing the way that doctors communicate prognosis to patients who have cancer, organ diseases or other terminal diagnoses, but this study shows that we still have room to grow in discussing life expectancy with frail older adults who have poor prognosis simply because of multiple physical or cognitive impairments or old age," added principal investigator Dr. Alexander Smith, a physician at SFVAMC and a bioethics expert and assistant professor of medicine in the division of geriatrics.

The study was published online Nov. 30 in the Journal of General Internal Medicine.

More information

The AGS Foundation for Health in Aging has more about communication between seniors and their doctors.

Source: http://us.rd.yahoo.com/dailynews/rss/seniors/*http%3A//news.yahoo.com/s/hsn/20111222/hl_hsn/mostsickordisabledseniorswantdocstosayhowlongtheyhave

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Monday, December 19, 2011

FDA Seeks to Get More Women Into Trials of Medical Devices (HealthDay)

FRIDAY, Dec. 16 (HealthDay News) -- Draft recommendations meant to increase the number of women in clinical trials for medical devices were released Friday by the U.S. Food and Drug Administration.

Genetics, hormones, body size, diet, social and cultural factors, and types of illness may cause women to respond differently to certain medical products and devices than men, according to the FDA.

But, women are typically underrepresented in clinical trials. For example, a 2009 study of applications for approval of cardiovascular devices found that average female enrollment in important trials that included gender information was only 33.9 percent.

The FDA's draft guidance -- intended for medical device developers and manufacturers -- includes recommendations for designing and conducting medical device clinical trials in a way that may increase the enrollment of women, said Dr. Jeffrey Shuren, director of the FDA's Center for Devices and Radiological Health.

"The FDA recommends that investigators and manufacturers strive to enroll representative proportions of both women and men in their device studies," he said in an FDA news release. "Our draft guidance outlines what we recommend for obtaining and improving the quality and consistency of sex-specific data on devices."

The document covers study and evaluation of sex differences, data analysis, and reporting in clinical studies conducted both before and after market approval. It also deals with statistical analyses of sex differences, how to report sex-specific information in summaries, and sex-specific labeling for approved devices.

There is a 90-day public comment period on the draft guidance.

More information

Here's where you can find the draft guidance.

Source: http://us.rd.yahoo.com/dailynews/rss/meds/*http%3A//news.yahoo.com/s/hsn/20111217/hl_hsn/fdaseekstogetmorewomenintotrialsofmedicaldevices

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