Friday, March 29, 2013

FDA approves new multiple sclerosis capsules

WASHINGTON (AP) ? The Food and Drug Administration said Wednesday it approved a new drug from Biogen Idec to control multiple sclerosis in adults with hard-to-treat forms of the disease.

The twice-a-day capsules, called Tecfidera, offer a new option for multiple sclerosis, a debilitating disease in which the body attacks its own nervous system. Cambridge, Mass.-based Biogen Idec already sells two other drugs for the disease, but both require injections.

There is no cure for multiple sclerosis and most patients experience relapses of symptoms, including loss of balance, weakness in arms and legs, and blurred vision. Over time patients usually become weaker and less coordinated. More than 2 million people worldwide have the disease, with about 400,000 of them in the U.S., according to Biogen.

The FDA said it approved Tecfidera based on two studies showing patients taking the drug had fewer relapses than patients taking a dummy pill.

The approval gives Biogen a new product in an increasingly crowded field of multiple sclerosis drugs.

The biotech drugmaker already sells the once-a-week multiple sclerosis injection Avonex. It also markets the once-a-month injection Tysabri through a partnership with Elan Corp. PLC of Ireland. However, Tysabri's severe side effects have curtailed its use.

Tecfidera is designed to be taken orally, which could make it a preferred option for patients and doctors.

A Biogen executive said Wednesday that its three drugs would be used to treat different groups of patients.

"Multiple sclerosis is a reasonably complex disease and we think there are a lot of needs out there," said Tony Kingsely, a vice president at Biogen. "By having three drugs out there I think we can address a lot of those needs."

Kinglsey said the company will announce the pricing of the drug when it begins shipping in the next week.

Novartis launched the first pill-based multiple sclerosis drug, Gilenya, in March 2011. Sanofi won FDA approval for a second pill, its drug Aubagio, last September.

The top-selling drug for the disease worldwide is Copaxone, which is made by Teva Pharmaceutical Industries. That injection had sales of nearly $4 billion last year, according to Teva's latest financial report.

Avonex and Tysabri had annual sales of $2.7 billion and $1.5 billion in 2011, the most recent year for which Biogen has reported annual sales.

Biogen Idec Inc. shares rose $5.59, or 3.2 percent, to close Wednesday at $182.68.

Source: http://news.yahoo.com/fda-approves-multiple-sclerosis-capsules-220534878.html

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Those Angry Days

Today we think of it as 'The Good War.' But Lynne Olson's excellent new book reminds us that, once upon a time, the question of US involvement in World War II was at least as contentious as Vietnam.?

By Danny Heitman,?Correspondent / March 27, 2013

Those Angry Days: Roosevelt, Lindbergh, and America?s Fight Over World War II, 1939-1941 by Lynne Olson Random House, 520 pp.

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Lynne Olson is best known for ?Citizens of London,? her 2010 bestseller about Americans who lived in London during the early days of World War II ? and their valor and ingenuity in advancing a US role in England?s success against the Nazis. She is also the author of ?Troublesome Young Men,? a 2007 chronicle of the upstart Tories who propelled Winston Churchill to the leadership of wartime Britain.

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In Those Angry Days: Roosevelt, Lindbergh, and America?s Fight Over World War II, 1939-1941, as in her earlier projects, Olsen focuses on a handful of key figures to plumb the broader historical currents sweeping events toward a dramatic milestone. ?Those Angry Days? also invites comparison to Olsen?s other work in revisiting one of her abiding preoccupations: the intersection between politics and war.

?Those Angry Days? takes its title from Arthur Schlesinger Jr., a New Deal Democrat and aide to John F. Kennedy who noted that the intensity of feeling regarding early US involvement in World War II has been largely forgotten. In the days before the Japanese attack on Pearl Harbor, when American interests in the widening global conflagration seemed less clear, the rift between isolationists and interventionists in the United States was wide and deep, said Schlesinger, who called the division ?the most savage?political debate of my lifetime.? He added this observation: ?There have been a number of fierce national quarrels ? over communism in the later Forties, over McCarthyism in the Fifties, over Vietnam in the Sixties ? but none so tore apart families and friendships as this fight.?

As Olsen notes in this absorbing chronicle, the bitterness of that debate has been obscured in postwar histories that focus on American unity and resolve after Dec. 7, 1941. In ?Those Angry Days,? she assigns herself the task of recreating the splintered political climate of 1939-1941, when American policy toward the war was very much in a state of flux.

?Those Angry Days? promises to benefit from some good timing, coming as it does on the heels of ?Lincoln,? the widely discussed Steven Spielberg film in which a compelling moral ideal ? in this case, racial equality ? operates against a backdrop of political expedience and sordid compromises. In Olsen?s story, the evolution of America?s role in World War II, a conflict now remembered as "The Good War" fought by "The Greatest Generation," reveals equally imperfect political realities.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/4xPK40iVUvk/Those-Angry-Days

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Sea Hare Squirts Sticky, Sense-Blinding Ink At Predatory Lobster (VIDEO)

By Matt Soniak

Sea hares don't look like they can put up much of a fight, but these bunny-eared slug cousins can really knock you senseless. When disturbed, sea hares (genus Aplysia) release a dark purple cloud that's made up of ink and a sticky, milky mix of chemicals called opaline.

Today in The Journal of Experimental Biology, researchers show that the opaline in the ink cloud not only frightens and distract predators, but also interferes with their sensory organs and blocks their chemical receptors.

To find its desensitizing secret, the scientists dabbed opaline extracts onto the antennae of spiny lobsters, which will hunt the hares when less well-defended prey is hard to come by. They then blasted some shrimp-scented water into the lobsters' tanks and watched how their chemosensory cells reacted to the smell of food.

They found that opaline's sticky components alone could significantly decrease the cellular activity, suggesting that opaline strikes predators chemically "blind" by gumming up their chemical senses.

See more videos.

Video Credit: Paul M. Johnson

ScienceNOW, the daily online news service of the journal Science.

Also on HuffPost:

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Source: http://www.huffingtonpost.com/2013/03/28/sea-hare-video-lobster-ink_n_2970520.html

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Google Introduces Same-Day Shipping to Compete With eBay and Amazon

Google Introduces Same-Day Shipping to Compete With eBay and Amazon
The people who brought you Android and Gmail now want to bring potato chips and diapers right to your home with a new same-day delivery service.

Source: http://feedproxy.google.com/~r/GearFactor/~3/1SFnBXxvfgI/

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Define your boundaries at work: work/life balance ? Business ...

While you may have to do some things you don?t love on the job, you shouldn?t have to continually operate outside your comfort zone, says Mike Figliuolo, author of One Piece of Paper: The Simple Approach to Powerful, Personal Leadership.

Try to establish a line that you won?t cross or allow others to cross with you. Since everyone?s line is different, the only way people will know about your line is to teach them about it and let them know your limits, within the boundaries of your boss/admin relationship.

First, define those limits. Figliuolo suggests you take some time to write down answers to these questions to help you out.

  • What kind of work is required for you to be happy with your job? Which specific tasks or activities do you find the most fulfilling?
  • What kind of work or tasks would you love to eliminate from your daily routine?
  • Which characteristics of your job would you like to maintain at all costs (e.g., flexibility, predictability, ambiguity, simplicity, complexity, independence)? In what kind of environment are you most productive?
  • What characteristics of your job would you like to eliminate (e.g., flexibility, complexity, etc.)? In which environments are you unproductive or unhappy?
  • How do you prefer your co-workers, bosses, and team members to interact with you? How do you prefer they not interact? What pet peeves do you have regarding how others treat you?
  • Do you know someone who has an outstanding balance of doing work they are thrilled with compared to work they do not enjoy? How do they achieve that mix? What can you change about your own approach to work to better emulate them?
  • Has there ever been a point in life where you had a good work/life balance? What were the circumstances surrounding that situation that made it work? ?? ??? ?

? Adapted from ?How to Set Better Boundaries at Work,? Mike Figliuolo, Thought Leaders.

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Ballpark to debut 'urinal gaming system' in Pa.

ALLENTOWN, Pa. (AP) ? Talk about streaming media: The Philadelphia Phillies' top minor league affiliate is set to debut what it calls a "urinal gaming system" at its ballpark in Allentown.

The Lehigh Valley IronPigs tapped a British company to install the system in men's restrooms at Coca-Cola Park.

It consists of a video display mounted above each urinal. When a fan approaches, the video console will sense his presence and switch into gaming mode. The guy aims left or right to control the play on the screen.

The team said Tuesday that Coca-Cola Park will be the first sports venue in the world to feature the gaming system. It'll be ready by opening day next week.

IronPigs General Manager Kurt Landes says he didn't want to flush away a golden opportunity to entertain fans. He says the games are "sure to make a huge splash."

Source: http://news.yahoo.com/ballpark-debut-urinal-gaming-system-pa-214737815.html

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Thursday, March 28, 2013

A CPA Reveals the 10 Biggest Tax Mistakes People Make

A CPA Reveals the 10 Biggest Tax Mistakes People Make1040, 1040A, 1040EZ, Schedule C, Schedule B, 1099, W-2?doing taxes is like trying to speak a foreign language that you've never taken a course in. Given how complicated the tax code is, it's not surprising that people mess up when filing their returns?and those mistakes can cost people thousands. As a Certified Public Accountant with his own boutique firm, Gary Craig has seen it all. He shares some of the most common tax blunders that he witnesses to ensure that your own filing goes smoothly.

A CPA Reveals the 10 Biggest Tax Mistakes People Make

Shopping for the Biggest Refund

Craig says that perhaps the biggest mistake is trying to find someone who will give you the largest refund without making sure that it's accurate. "I got a guy last year who came in at the very last minute on April 10," says Craig. "He and his wife filed separately to take more exemptions, and the tax preparer he'd initially used was really aggressive about reimbursing. The guy was flabbergasted by how much he still owed and came to me ?refund shopping' to see if I could lower his tax liability, and I had to tell him, ?You actually owe more,' because the other preparer was so aggressive with the deductions."

Not Making Sure That Your Tax Preparer Signs the Return

If your tax preparer is confident in the accuracy of the return that he's prepared for you, then he'll have no trouble putting his name on it. But if he doesn't sign the return, it could be a sign that he's done something shady. In fact, Craig says, "If [the mistakes on your return are] serious and seem intentional, you can report him to the IRS. That's grounds for losing one's license."

Being Too Aggressive With Unreimbursed Business Expenses

This mistake has an easy solution: In addition to keeping those receipts for unreimbursed business expenses, always keep a record of your company's reimbursement policy?even for past years. This is the only document that will save you in an audit. Without it, the IRS won't recognize those expenses.

Taking Inappropriate Real Estate Deductions

If you're not a real estate professional, and you make more than $150,000, you can't take losses on any rental properties that you own against your normal working wages in order to lower your taxable income. Take it from Craig: "I had a client making $300,000, and taking $160,000 in real estate losses"?none of which was allowed. His bill? A cool $50,000 in back taxes and penalties.

A CPA Reveals the 10 Biggest Tax Mistakes People Make

Inflating the Value of a Car That You Donate

"This has been really popular the last few years," says Craig, "but IRS regulations around that have become more stringent in terms of documenting the value. If you've got a 1985 Toyota Corolla sitting in your garage, and you donate that vehicle to charity, claiming it's worth $1,500, you'd better have good documentation to support that value." His recommendation: Start with the Kelley Blue Book value. And if you make any improvements to the car, keep the receipts so you can prove their worth.

Being Too Aggressive With Home Office Deductions

This year, the IRS changed the requirements on the home office deduction for the 2013 tax year (to be filed in 2014). Under the new rule, taxpayers have the option to take a "standard" home office deduction of $5 for every square foot of office space up to 300 square feet. In the interim, the home office deduction could trip up those filing for it in the 2012 tax year, so make sure to measure your square footage correctly.

Misunderstanding the Stock Transactional Wash Sale Rule

Let's say you buy a few shares of Facebook stock, and then you later sell them at a small loss. Normally, you could deduct that loss against any other capital gains you made that year in order to lower your taxes. But if you bought more stock 30 days after selling (or 30 days before selling), then the first sale is disregarded. "It's like you never sold the stock in the first place," says Craig. And you won't get the tax benefit.

Not Taking Advantage of Traditional IRA Deductions

Here's a "mistake" that you can retroactively use to lower your taxes in the previous year. Plus, it also boosts your retirement savings! If you have a 401(k) at work, you can also contribute to your retirement savings in a traditional IRA and get a tax deduction if your income falls under the income limits. (For 2012, singles making $58,000 or below and those married filing jointly making $92,000 or below can contribute the full $5,000 to their IRAs; singles with income between $58,000 and $68,000 and married couples with income between $92,000 and $112,000 can make partial contributions.) So let's say that it's 2013, and you realize that you didn't contribute the full amount allowed to you for your IRA for 2012. You can still make a contribution now that will count for 2012, lowering your taxes for that year.

A CPA Reveals the 10 Biggest Tax Mistakes People Make

Neglecting to Tell Your Tax Preparer About Life Changes

Although things that happen in your family life or your job may seem unrelated to your taxes?and therefore none of your CPA's business?they can affect how much you owe. "Maybe your mother has moved in and is dependent on you, or your kids are now old enough to be in daycare," says Craig. "Tell your CPA what's going on in your life instead of just bringing him a bundle of forms." For instance, if you've changed jobs, your CPA could help you structure your compensation to maximize tax savings.

Settling for a CPA Who Just Goes Through the Motions

"Find a tax preparer who knows and cares about what makes you you," says Craig. Your CPA should know what brings you pleasure in life, what kind of family you have and what your values are. This way, for instance, he or she can help you make sure you're meeting your retirement goals with smart tax planning. Also, according to Craig, "the CPA can look out for opportunities to bring you during the year."

A CPA Spills: The 10 Biggest Tax Mistakes That I See?LearnVest


Laura Shin is the senior editor at LearnVest. She has worked at Newsweek.com, WSJ.com and NYTimes.com, and, as a freelancer, has had her writing published in the New York Times, The Wall Street Journal, The Los Angeles Times, and others. She graduated Phi Beta Kappa with Honors from Stanford University with a degree in Modern Thought and Literature and has a master of arts from Columbia University's School of Journalism. An avid traveler who has lived in Indonesia, visited Italy seven times, and trekked in the Himalayas in northern India, she is saving up for the 2014 World Cup in Brazil. Follow Laura on Twitter @LauraShin.

Illustration by Tina Mailhot-Roberge.

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Source: http://feeds.gawker.com/~r/lifehacker/full/~3/pSCaETNqMYM/a-cpa-reveals-the-10-biggest-tax-mistakes-people-make

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GOP moves to catch up with Democrats on technology

WASHINGTON (AP) ? Republicans are moving aggressively to repair their technological shortcomings from the 2012 election, opening a new tech race to counter a glaring weakness against President Barack Obama.

With the blessing of party leaders, a new crop of Republican-backed outside groups is developing tools to improve communication with voters, predict their behavior and track Democratic opponents. After watching Obama win re-election with the aid of an unprecedented technological machine, GOP officials concede an urgent need for major changes in the way they reach voters. They are turning to a younger generation of tech experts expected to play a bigger role in the 2014 midterm elections and beyond.

"I think everybody realized that the party is really far behind at the moment and they're doing everything within their realistic sphere of influence to catch up," said Bret Jacobson, a partner with Red Edge, a Virginia-based digital advocacy firm that represents the Republican Governors Association, the U.S. Chamber of Commerce and the Heritage Foundation.

Alex Skatell, former digital director for the GOP's gubernatorial and Senate campaign operations, leads a new group that has been quietly testing a system that would allow Republicans to share details about millions of voters ? their personal interests, group affiliations and even where they went to school. Democrats began using related technology years ago, giving Obama a significant advantage last fall in personalizing communication with prospective supporters.

With no primary opponent last year, Obama's re-election team used the extra time to build a large campaign operation melding a grass-roots army of 2.2 million volunteers with groundbreaking technology to target voters. They tapped about 17 million email subscribers to raise nearly $700 million online.

Data-driven analytics enabled the campaign to run daily simulations to handicap battleground states, analyze demographic trends and test alternatives for reaching voters online.

Republican presidential nominee Mitt Romney, in contrast, had only a few months after a lengthy primary fight to try to match Obama's tech advantage. He couldn't make up the difference. Romney's technology operation was overwhelmed by the intense flow of data and temporarily crashed on Election Day.

A 100-page report on how to rebound from the 2012 election, released last week by Republican Party Chairman Reince Priebus, includes several technology recommendations.

"The president's campaign significantly changed the makeup of the national electorate and identified, persuaded and turned out low-propensity voters by unleashing a barrage of human and technological resources previously unseen in a presidential contest," the report said. "Marrying grass-roots politics with technology and analytics, they successfully contacted, persuaded and turned out their margin of victory. There are many lessons to be learned from their efforts, particularly with respect to voter contact."

Skatell, 26, is leading one new effort by Republican allies to fill the void. His team of designers, software developers and veteran Republican strategists is now testing what he calls an "almost an eHarmony for matching volunteers with persuadable voters" that would let campaigns across the country share details in real time on voter preferences, harnessing social media like Facebook and Twitter.

Other groups are working to improve the GOP's data and digital performance.

The major Republican ally, American Crossroads, which spent a combined $175 million on the last election with its sister organization, hosted private meetings last month focused on data and technology. Drawing from technology experts in Silicon Valley, the organization helped craft a series of recommendations expected to be rolled out later this year.

"A good action plan that fixes our deficiencies and identifies new opportunities can help us regain our advantage within a cycle or two," said Crossroads spokesman Jonathan Collegio.

A prominent group of Republican aides has also formed America Rising, a company that will have a companion "super" political action committee that can raise unlimited contributions without having to disclose its donors. Its purpose is to counter Democratic opposition research groups, which generated negative coverage of Romney and GOP candidates last year.

America Rising will provide video tracking, opposition research and rapid response for campaign committees, super PACs and individual candidates' campaigns but does not plan to get involved in GOP primaries. It will be led by Matt Rhoades, who served as Romney's campaign manager, and Joe Pounder, the research director for the Republican National Committee. Running its super PAC will be Tim Miller, a former RNC aide and spokesman for former GOP presidential candidate Jon Huntsman.

Romney and several Republican candidates were monitored closely by camera-toting Democratic aides during the campaign, a gap that Miller said American Rising hopes to fill on behalf of Republicans.

Brad Woodhouse, a spokesman for the Democratic National Committee, said his party has "a several years' lead on data and analytics infrastructure and we're not standing still."

Of the GOP effort, Woodhouse said, "We don't see them closing the gap anytime soon."

___

Peoples reported from Boston.

Source: http://news.yahoo.com/gop-moves-catch-democrats-technology-065816379--election.html

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HTC One camera tips: How to take better pictures

HTC One camera

A few simple tips will help you get better pictures from your HTC One

The HTC One's "Ultrapixel" camera is one of its main selling points, as is the vast assortment of photo features arranged around it. But knowing how to get the most out of the camera hardware and its array of software options isn't always easy, which is why we've come up with a quick guide to walk you through the best way to using the HTC One's camera features.

If you're picking up an HTC One this week in Europe or Asia -- or you're planning on taking the plunge in the weeks ahead -- you'll want to check it out after the break.

read more



Source: http://feedproxy.google.com/~r/androidcentral/~3/lnKCGCmi5HE/story01.htm

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Supreme Court DOMA Case: Justices Question Whether They Can Even Decide Dispute

WASHINGTON -- A majority of Supreme Court justices on Wednesday morning appeared skeptical of the constitutionality of the Defense of Marriage Act (DOMA), which defines marriage for federal purposes as between a man and a woman. Whether the justices believe they have the power to make any decision in this case, however, remained murky.

It was the second day in a row that the high court heard arguments dealing with same-sex marriage. At issue Wednesday in United States v. Windsor was whether it was constitutional for the U.S. government to refuse to recognize same-sex marriages that had been recognized by the states.

Justice Anthony Kennedy, who said Tuesday that the children of same-sex couples ?want their parents to have full recognition and legal status,? seemed troubled by the fact that DOMA refuses to recognize even those same-sex unions that are already recognized by states.

"When the federal government has 1,100 laws, which means in our society the federal government is intertwined with citizens' day-to-day lives," Kennedy said, then Congress is doing more than simply ensuring a uniform definition of marriage.

DOMA was only helping states, Kennedy said, ?if they do what we want them to do.? He pointed out to Paul Clement, the lawyer defending DOMA, that the law applied to states ?where voters have decided? to legalize same-sex marriage and stated that he believed there was injury to same-sex couples whose marriages were not recognized by the federal government.

Section 3 of DOMA, at issue in Wednesday morning's case, says "the word 'marriage' means only a legal union between one man and one woman as husband and wife" for purposes of "any Act of Congress, or of any ruling, regulation, or interpretation of the various administrative bureaus and agencies of the United States."

Plaintiff Edie Windsor, 83, brought suit against the federal government after the Internal Revenue Service cited DOMA in denying her a refund for the $363,000 in federal estate taxes she paid following the 2009 death of Thea Spyer, her partner for over 40 years. Windsor and Spyer had married in Canada in 2007, but resided in New York. Because Windsor would have been eligible for an estate tax exemption had Spyer been a man, she argues that DOMA's Section 3 violates her equal protection rights under the Fifth Amendment.

On this point, Windsor had a friend in Justice Ruth Bader Ginsburg, who said that DOMA created "two types of marriage," likening same-sex marriage in the states to the "skim milk" version of straight unions.

Justice Kennedy also showed hostility to DOMA. But like his position in the Proposition 8 oral arguments Tuesday, he appeared reluctant to rule on equal protection grounds. Instead, the question for him was "whether or not the federal government under our federalism scheme has the authority to regulate marriage."

Solicitor General Donald Verrilli, representing the Obama administration on the merits of the case, avoided Kennedy's question, choosing instead to emphasize Congress' discriminatory purpose in enacting DOMA in 1996.

The law "is not called Federal Uniform Definition of Marriage Act," he said. "It's called the Defense of Marriage Act."

Justice Elena Kagan pushed a similar point. She told Clement, who was defending DOMA on behalf of the House of Representatives' Bipartisan Legal Advisory Group, "that maybe Congress had something different in mind than uniformity" in the definition of marriage. Suggesting the law was "infected with prejudice, fear, spite, and animus," Kagan read a portion of the House Report, which said DOMA was meant to reflect Congress' "collective moral judgment and to express moral disapproval of homosexuality."

Perhaps key to the justices' analysis of the case is whether to regard laws that single out gays and lesbians with what's called "heightened scrutiny" -- a level of review now used to strike down measures that single out politically disfavored and less powerful groups.

On this point, Chief Justice John Roberts focused in on the ?sea change? in public opinion on the question of same-sex marriage. How did that ?sea change? come about, he asked, unless gay and lesbian Americans had amassed significant political power. Roberts said it seemed to him that politicians were ?falling over themselves? to endorse gay marriage.

Roberts also wondered why, if President Barack Obama believes DOMA is unconstitutional, he continues to enforce it. ?I don?t see why he doesn?t have the courage of his convictions,? the chief said. Kennedy chimed in later, saying he didn?t ?understand why they continue to enforce? DOMA.

Clement said that if 10 years from now, there were only nine states left that didn?t have gay marriage, the federal government might be fully entitled to force the remaining states to recognize such unions.

Judging from Wednesday's first 50 minutes of oral arguments, however, the case may instead be decided on whether the justices have the power to hear the case at all.

In United States v. Windsor, the U.S. District Court and the U.S. Court of Appeals for the 2nd Circuit both declared DOMA unconstitutional. The Obama administration agrees with them.

Chief Justice Roberts asked Deputy Solicitor General Sri Srinivasan, arguing on behalf of the Obama administration, whether there was "any case where all parties agreed with the decision below," but a court "nonetheless upheld" its ability to hear the case.

The chief's question about legal standing reflects DOMA's long, strange trip to this point. A bipartisan piece of legislation, it was signed into law in 1996 by President Bill Clinton, who now believes it should be overturned.

In 2010, a Department of Justice official told reporters that defending DOMA was ?difficult? for the Obama administration, while Attorney General Eric Holder told D.C. law students that the DOJ ?has a responsibility to defend those statues that the Congress has passed if there is an argument that can be made to defend those statutes."

But things changed in 2011, when Holder announced that the DOJ would no longer defend DOMA. Holder was not in the courtroom on Wednesday, but Deputy Attorney General James M. Cole and Acting Assistant Attorney General Stuart Delery, who runs the DOJ's Civil Division, were in attendance on behalf of the department.

After the DOJ backed off from defending the law, House Republicans stepped in. The Bipartisan Legal Advisory Group hired Clement, George W. Bush?s former solicitor general, to defend the law on behalf of the federal government.

Clement faced difficult questioning Wednesday from the Supreme Court's liberal wing on why the House had any legally recognizable interest in representing a position the executive has abandoned.

"How is this case any different from enforcing general powers of the United States," Justice Stephen Breyer asked.

See photos from the Supreme Court below, and scroll down for live blog updates:

HuffPost's Lila Shapiro reports:

Bonnie Quesenberry and Fay Jacobs celebrated their 31st anniversary in front of the Supreme Court on Wednesday. It would have been their 31st wedding anniversary had marriage been legal for same-sex couples back when they got together, in 1982, after meeting at a conference at John Hopkins University.

Quesenberry, a retired dental lab technician, wore small purple sunglasses, and Jacobs, a writer, wore black fleece. As the two women waited on the steps to hear how the arguments in the case against the federal Defense of Marriage Act inside the court were going, they bumped into another lesbian couple, also together for 31 years.

"We're the 31 club!" Jacobs exclaimed, holding out her home-made banner, which read, "If Gay Marriage were LEGAL Today would be our 31st Anniversary," and laughing.

"We've had congratulations said 1,000 times," Quesenberry said, as the four women all embraced. "This just couldn't be better."

Read more here.

As protesters rally in support of nixing DOMA outside of the Supreme Court on Wednesday, across the street in the U.S. Capitol, only a handful of House Republicans agree with their stance. Three, to be exact.

Jimmy LaSalvia, the executive director of the gay conservative group GOProud, said he couldn't understand why House Republicans aren't talking about the need to repeal DOMA. After all, he said, even conservatives who oppose same-sex marriage agree that the law is unconstitutional.

"At this point, I'm absolutely baffled," LaSalvia told The Huffington Post. "I don't think they're done losing yet. What do you think? I think it's because they're not done losing yet."

LaSalvia said true conservatives know the Constitution leaves issues relating to marriage and family law up to the states. In the case of DOMA, that fact is "particularly important" from a constitutionally conservative point of view, he said.

House Republicans "appear to be the only ones in America who think that DOMA is constitutional," he said. "The establishment leaders in Washington in the Republican Party are continuing to demonstrate how out of touch they are with Americans."

One shift has occurred among Republican lawmakers in recent years, from openly trashing gay marriage during speeches on the House floor to mostly just staying silent on the issue. But LaSalvia said that doesn't count as progress for his party.

"So now they've become the 'don't say gay' group," he said. "But that still makes them look out of touch because everyone else in the country is talking about it!"

--Jennifer Bendery

The 83-year-old plaintiff in the Defense of Marriage Act case spoke to media after being heard by the U.S. Supreme Court, but her remarks emphasized the human angle of her "overwhelming" fight rather than strictly economics.

Read more here.

WASHINGTON -- Michelle McFadden, 33, came out to the Supreme Court to advocate for marriage equality on Tuesday, but on Wednesday she decided to return with a special guest: her five-year-old daughter, Bailey.

"This is history. I came out a second day in a row to bring my 5-year-old daughter, because the issue affects her as much as it affects me and my wife," McFadden said.

Bailey held a sign reading, "Let my parents be married because they love each other and because I love them too!" while McFadden's sign read, "Kids need unconditional love, not your hate. Shame on you."

McFadden said she and her wife, who live in Maryland, married last year after 15 years together.

When asked what repealing DOMA would mean for her and her wife, McFadden replied, "Benefits."

"I'm a stay-at-home mom to our two kids, and my wife works for the federal government," she said. "I don't get her benefits because of DOMA. So the repeal of DOMA would mean I get health insurance for the first time in three years."

Bailey, when asked what she thought of being at the Supreme Court for the historic case, simply replied, "I think it's cool."

Watch an interview with McFadden and her daughter:

-- Amanda Terkel

WASHINGTON -- Jo Deutsch, 53, and Teresa Williams, 56, have been together for nearly 30 years. And on May 18, they're finally getting married.

"We have three kids, and we want them to have the same rights as all of their friends by having us have the opportunity to get married," Williams said.

The two joined hundreds of people at the Supreme Court on Wednesday to advocate for the repeal of the Defense of Marriage Act. Both were wearing pink ribbons reading, "Bride To Be."

When asked whether they ever expected to be seeing so much progress on LGBT rights, Deutsch -- who works for the group Freedom to Marry -- replied, "We never thought we'd be buying wedding dresses in our lifetime, but we've done that, too!"

Watch an interview with Deutsch and Williams:

-- Amanda Terkel

WASHINGTON -- For Anna Olsson, 41, and her partner, Michelle Bailey, 46, a Supreme Court decision to strike down the Defense of Marriage Act has potentially huge consequences in their lives: It means they would get to stay in the United States.

Olsson, who is from Sweden, is in America on a work visa -- meaning she doesn't have a green card or U.S. citizenship.

"I basically have no guarantee for staying here, whereas if I were marrying a man, I would instantly be granted a green card and potentially citizenship," Olsson told The Huffington Post.

The couple came out to the Supreme Court on Wednesday morning, with hundreds of other marriage equality supporters, to show their support for the end of DOMA. Federal law defines marriage as being between one man and one woman, meaning that even couples who are legally married in their states are denied federal benefits -- such as on immigration matters.

Olsson and Bailey are currently living in Takoma Park, Md. When asked how she felt about the prospect of moving to Sweden, Bailey replied, "I think Sweden would be fantastic, but I would rather do it because I want to move, not because I'm forced out of my own country just because I want to have the same equal rights as anybody does to protect their family and their loved ones. This is what this is about. ... I would love Sweden, but I love this country and I want to stay here."

Watch an interview with Olsson and Bailey:

@ jbendery : Pelosi on Paul Clement defending DOMA in court: "What a stale role to play in life."

Stateline, a daily news service of Pew Charitable Trusts, created an interactive graphic showing the Justices' remarks on DOMA in their own words.

Click here for more from Pew's Stateline.

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Source: http://www.huffingtonpost.com/2013/03/27/supreme-court-doma_n_2952611.html

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Crucial Search Engine Marketing Strategies That Really Work | SEO ...

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Honest and exact description tag are essential to get visitors from search engine listings aimed at your website. This helps boost your SEO. While the tag is very important, too much size is a bad thing. Limit the label into a to the point 30 words. You need to never ever go higher than 100 KB on the web page.

You can attempt setting up a robot. txt file that explores the root?s directory site. This technique conceals specific files from being reached on your internet site.

The meta labels should include a good outline of the web page information. All effectively-created meta tags should be each accurate and alluring.

Market your expertise in your unique industry, which means your clients know about your measure of expertise. This promotional tool can be quite helpful. Style your site around a particular niche market, and utilize Search engine optimization techniques to generate those potential customers for your site so they can purchase products. Get comments out of your clients relating to their personal preferences. This can help you figure out the most effective services and products to supply.

As you have discovered, Search engine marketing is essential to the prosperity of any business online. Have a duplicate with this post, and make reference to it while you are adding its techniques to use. A greater web site will get a boost in traffic and produce more money to suit your needs.

Source: http://www.rathenauinstituut.com/crucial-search-engine-marketing-strategies-that-really-work/

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Suspected Tacoma, Washington gunman in custody after standoff

Ed Troyer / Pierce County Sheriff via AP

Deputies take Mike McBee into custody in Tacoma, Wash. Tuesday, after he allegedly walked down the street firing guns at houses and then barricaded himself in his home. This photo was provided by the Pierce County Sheriff's Dept.

By M. Alex Johnson, staff writer, NBC News

A man who reportedly walked through a Tacoma, Wash., neighborhood spraying gunfire was taken into police custody after a standoff at his residence, Seattle TV station KING 5 reported.

Police had surrounded the home Tuesday afternoon, where the man with at least four high-powered weapons was holed up, a sheriff's official told NBC News.

Pierce County Sheriff's Department told KING that the suspect was 67-year-old Mike McBee, a Vietnam veteran.

No injuries were reported, but Pierce County sheriff's Detective Ed Troyer said several homes were hit by bullets in the neighborhood in Tacoma, about 30 miles of Seattle.

Troyer, speaking before the suspected was named, said the gunman was known to have "mental health issues" and was believed to have been drinking.

Police began firing tear gas into the house early Tuesday evening, KING reported.

KING reported that numerous residents of the neighborhood had been evacuated and that those who remained were asked to stay inside.

Troyer told KING that the suspect had substance abuse issues.

NBC News' Denise Ono and Ian Johnston contributed to this report.

This story was originally published on

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/2a08b563/l/0Lusnews0Bnbcnews0N0C0Inews0C20A130C0A30C260C174778240Esuspected0Etacoma0Ewashington0Egunman0Ein0Ecustody0Eafter0Estandoff0Dlite/story01.htm

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Monday, March 25, 2013

Swedish House Mafia Had Ultra Music Fest Climbing Porta-Pottys

Fans were dripping in each other's sweat to catch a glance of the threesome during the second weekend of Miami's EDM party.
By Sarah Harper


Swedish House Mafia perform at Ultra
Photo: Getty Images

Source: http://www.mtv.com/news/articles/1704272/swedish-house-mafia-tiesto-ultra.jhtml

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Prince Harry to visit US, skipping Vegas this time

FILE - In this Sunday March 11, 2012 file photo Britain's Prince Harry gives a thumbs up during the award ceremony after playing a charity polo match in Campinas, Brazil. St. James's Palace say Monday March 25, 2013, Prince Harry is returning to the United States ? but this time he's skipping Las Vegas. (AP Photo/Andre Penner, File)

FILE - In this Sunday March 11, 2012 file photo Britain's Prince Harry gives a thumbs up during the award ceremony after playing a charity polo match in Campinas, Brazil. St. James's Palace say Monday March 25, 2013, Prince Harry is returning to the United States ? but this time he's skipping Las Vegas. (AP Photo/Andre Penner, File)

(AP) ? Britain's Prince Harry is returning to the United States ? but this time he's skipping Las Vegas.

The 28-year-old prince will travel to the U.S. East Coast as well as Denver and Colorado Springs, Colorado, to support veterans' charities and get in a bit of polo.

Harry, a longtime supporter of charities that rehabilitate war veterans, will attend several events at the 2013 Warrior Games, a competition in which veteran athletes from both Britain and the United States take part.

"Prince Harry wants to highlight once again the extraordinary commitment and sacrifice of our injured servicemen and women," said Jamie Lowther-Pinkerton, Harry's private secretary.

Harry recently spent 20 weeks in Afghanistan as co-pilot gunner on an Apache attack helicopter.

His May 9-15 visit will include trips to Arlington National Cemetery, Walter Reed National Medical Center and an exhibition on Capitol Hill about land mine clearance, a favorite subject of his late mother, Princess Diana. He will also visit areas in New Jersey hard hit by Hurricane Sandy.

Harry will also play in the Sentebale Polo Cup in Greenwich, Connecticut. Sentebale ? which means "forget-me-not" ? is a charity founded by Harry and Lesotho's Prince Seeiso that helps children struggling with poverty in the tiny southern African country.

On his last U.S. visit, the third-in-line to the British throne stormed last year into the headlines when he was caught frolicking in the nude with a woman after an alleged game of strip billiards in his Las Vegas hotel room.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-03-25-Britain-Prince%20Harry/id-c199d4d8dbe8405e844cd435f2fce227

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Catalyst in a teacup: New approach to chemical reduction

Mar. 24, 2013 ? Taking their inspiration from nature, scientists at the University of New South Wales have developed a new method for carrying out chemical reduction -- an industrial process used to produce fuels and chemicals that are vital for modern society.

Their catalyst-based approach has the big advantages that it uses cheap, replenishable reagents and it works well at room temperature and in air -- so much so, it can even be carried out safely in a teacup.

The research, by a team led by Associate Professor Stephen Colbran, of the UNSW School of Chemistry, has been published as the cover of the journal, Angewandte Chemie.

The catalyst they designed mimics the activity of naturally occurring enzymes that catalyse reduction, such as alcohol dehydrogenase in yeast, that helps produce alcohol from sugar.

"Industrial chemical reduction processes underpin human existence, but are unsustainable because they irreversibly consume reagents that are made at prohibitively high energy cost," Dr Colbran says.

"We believe our new biomimetic design may have wide applications in chemical reduction."

Chemical reduction involves the addition of electrons to a substance, and is the basis of making many fuels, including the sugars that plants produce during photosynthesis.

In industry, molecular hydrogen and reactive reagents such as sodium borohydride are used as reducing agents during the production of pharmaceuticals, agrichemicals and ammonia for fertiliser.

"Manufacture of these substances is energy costly, leads to the release of carbon dioxide and they are difficult to handle and store," Dr Colbran says. "So we decided to look at nature to see how nature does it."

The team combined a transition metal complex containing rhodium with a Hantzsch dihydropyridine -- an organic donor of a hydride ion similar to biological nicotinamides -- to produce the new bio-inspired catalyst. They tested it on a common process -- reduction of imines -- and were surprised to find it worked in ambient conditions with more than 90 per cent efficiency in most cases.

Dr Colbran even tested it out in a teacup. "I thought it would be a bit of fun. And it makes a serious point -- our catalyst system is very easy to use."

By coincidence, the research comes exactly a century after Alfred Werner won a Nobel Prize for Chemistry for his work on the structures of transition metal complexes. As well, his PhD supervisor, Arthur Hantzsch, discovered the way to synthesise dihydropyridines.

"It has only taken 100 years to combine the work of doctoral adviser and student into one molecule," Dr Colbran says.

A future aim is to try to convert the greenhouse gas, carbon dioxide, into the renewable fuel, methanol, much more efficiently.

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Story Source:

The above story is reprinted from materials provided by University of New South Wales.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Alex McSkimming, Mohan M. Bhadbhade, Stephen B. Colbran. Cover Picture: Bio-Inspired Catalytic Imine Reduction by Rhodium Complexes with Tethered Hantzsch Pyridinium Groups: Evidence for Direct Hydride Transfer from Dihydropyridine to Metal-Activated Substrate (Angew. Chem. Int. Ed. 12/2013). Angewandte Chemie International Edition, 2013; 52 (12): 3283 DOI: 10.1002/anie.201301157

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/sapSPw1VCVg/130325111214.htm

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McDonald's franchises in China need 5 years to break even

Source: Want China Times

McDonald's franchises in China may need up to five years before they break even, according to the Shanghai-based First Financial Daily.

Chinese investors interested in taking up a new McDonald's franchise must pay an initial fee of 2 million yuan (US$320,000) and must also pay for the building itself, equipment and other additional costs, including monthly franchising operations and advertising fees. An outlet may need to operate for five years before it starts to see a profit, based on the current sales of a typical McDonald's restaurant and the increasing cost of running a business in the country, analysts say.

The US fast food giant is continuing to expand its China network, with new franchises licensed in Hunan province last September, and the Jiangsu Rongjin Group obtaining franchise rights last October. McDonald's has also opened more outlets in Fujian and Sichuan provinces, according to sources familiar with the business.

McDonald's is one of the world's highest-grossing fast food chains and derives its profits from other channels in addition to its burgers, selling franchising and property as well as renting out its outlets. The company reported operating revenue of US$9.9 billion in 2011. Total business from its restaurants, franchising fees and rents accounted for 32%, 23% and 45% of operating revenue, respectively.

However, the company has failed to successfully apply its standard business model in China. Rival KFC beat McDonald's into China and has held the lead in terms of revenue and expanding its franchises over the past 20 years.

McDonald's hopes to expand its network in mainland China from 1,500 to 2,000 restaurants by the end of 2013 and 20%-30% of its restaurants will be franchise outlets by 2015. According to analysts, McDonald's should work more closely with agents within China to better understand the local market.

Source: http://www.chinabevnews.com/2013/03/mcdonalds-franchises-in-china-need-5.html

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Level One Network Blog - Blogging Made Easy - Why Online ...

Why Online Marketers Need A Level One Network Blog

I was just visiting our Level One Network group on Facebook and saw someone mention how happy they were that the blog post they did for their company is outranking even the company site. This is why I feel that anyone doing business online should have a Level One Network Blog.

A Level One Network Blog Can Give You an Edge on Your Competition
Let's face it. If you are marketing online, whether it's to sell your own products or promote some sort of mlm or direct sales business you are going to have a lot of competition. But not just competition from other companies. Most of your competition is going to come from others within your company. That's why you need a high ranking blog.?

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level one network blog

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Your Own Blog Will Bring Laser Targeted Traffic to Your Business
Let me give you an example. Lets say I was with a specific company selling nutritional products. If I wanted to drive targeted traffic to my blog I would be better off blogging about my specific company, not just nutritional products in general. And I could write several blog posts to do that and here is how:

  • A post about the business opportunity
    ?
  • A post about why I love the products
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  • A separate post promoting each specific product, what it is used for and why I like it.
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  • A post announcing new products being offered.
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  • Another post about the business opportunity (current specials coming up, etc).
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Notice how many blog posts you can do just talking about your company!

That is why you need a Level One Network blog! You need to brand yourself and get an edge over the competition! Because if people are doing searches about your company or any of the products, and you have a lot of posts out there on the search engines then chances are good that you will get very targeted visitors to your blog.

Why You Should Choose a Level One Network Blog
I have used many blogging platforms in the past, from self hosted Wordpress blogs to free sites like Blogger and Squidoo. And the fact is you always want to go with a paid blogging platform when marketing your business. Why? Because with free sites like blogger and Squidoo you have no control. And if they don't like your content they will delete it in a heartbeat.?

I have also done my own self hosted Wordpress blogs. However, not only is there a huge learning curve to figuring out Wordpress, but you are basically on your own to drive traffic to you blog. However, blogging on Level One Network solves that problem.

Level One Network Blogs are Designed to Rank Well
Marketing on the internet is tricky, and the competition is certainly stiff!? That''s why you want to blog on an authority site that will level the playing field. And not only are Level One Network blog posts ranking really well., but the built in tools provided will teach you everything you need to know to get the search engines to love your posts!.

Level One Network Business Opportunity
What is neat about Level One Network is the fact that it not only offers a great platform for anyone who wants to blog, but it also offers a lucrative, 100% commission business model. In fact, many people (myself included) came here to blog about another business or to do affiliate marketing but soon found out how easy it is to earn a great income from the Level One Network business.

But what about those who don't wish to promote another business or use their Level One Network blog for affiliate marketing? What about those who only want to promote Level One Network?

If you want to join Level One Network for the business opportunity with nothing else to promote then that's where you can get really creative! Simply blog about whatever interests you, such as a favorite hobby, recipes, how to tips, etc. You can also do blog posts about why you chose Level One Network and post updates on your progress. Then, at the end of each blog post you write a simple call to action to invite others to learn about your business and how they can get their own Level One Network blog.

How to Get Your Own Level One Network Blog
Are you ready to take action and start marketing on the internet with your own Level One Network blog? It's really easy and the step by step training is the most comprehensive blogging course I have ever seen, which is not just newbie friendly but for advanced bloggers as well!? Once you join you can go at your own pace and you will be a blogging expert in no time! Just watch this video to learn more!

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Source: http://www.levelonenetwork.com/wahmonline/why-online-marketers-need-a-level-one-network-blog/

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Baby Girl on the Way Jaime Ray Newman

The Red Widow star and her husband, writer/director Guy Nattiv, are expecting their first child - a daughter - this summer, Newman's rep tells PEOPLE exclusively.

Source: http://feeds.celebritybabies.com/~r/celebrity-babies/~3/z37zmDzNZ-c/

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Page Not Found - Yahoo!

Please check the URL for proper spelling and capitalization. If you're having trouble locating a destination on Yahoo!, try visiting the Yahoo! homepage or look through a list of Yahoo!'s online services.

Please try Yahoo Help Central if you need more assistance.

Source: http://rss.news.yahoo.com/rss/weightloss

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Art world shivers at sale of Henry Moore statue

This undated photo made available on Friday March 22, 2013 by the Yorkshire Sculpture Park shows the Henry Moore "Draped Seated Woman" statue, on loan to the Yorkshire Sculpture Park by the London borough of Tower Hamlets, in Wakefield, England. The cash-strapped London borough of Tower Hamlets, one of the poorest communities in Britain, plans to sell the statue, estimated to be worth as much as 20 million pounds ($30 million). (AP Photo/Jonty Wilde, Yorkshire Sculpture Park) EDITORIAL USE ONLY

This undated photo made available on Friday March 22, 2013 by the Yorkshire Sculpture Park shows the Henry Moore "Draped Seated Woman" statue, on loan to the Yorkshire Sculpture Park by the London borough of Tower Hamlets, in Wakefield, England. The cash-strapped London borough of Tower Hamlets, one of the poorest communities in Britain, plans to sell the statue, estimated to be worth as much as 20 million pounds ($30 million). (AP Photo/Jonty Wilde, Yorkshire Sculpture Park) EDITORIAL USE ONLY

(AP) ? The massive bronze sculpture is formally known as "Draped Seated Woman," a Henry Moore creation that evoked Londoners huddled in air raid shelters during the Blitz.

To the East Enders who lived nearby, the artwork was known as "Old Flo," a stalwart symbol of people facing oppression with dignity and grace.

But now, Old Flo may have to go.

The cash-strapped London borough of Tower Hamlets, one of the poorest communities in Britain, plans to sell the statue ? estimated to be worth as much as 20 million pounds ($30 million).

Art lovers fear the sale of such a famous sculpture would set a worrisome precedent, triggering the sell-off of hundreds of lesser works housed in parks, public buildings and little local museums as communities throughout Britain struggle to balance their budgets amid the longest and deepest economic slowdown since the Great Depression.

"If the sale of Old Flo goes through, it can open the flood gates," said Sally Wrampling, head of policy at the Art Fund, the national fundraising charity for art and one of the groups campaigning to block the sale.

The proposal embodies a dilemma faced by many struggling households: Do you sell the family silver to get through tough times?

Tower Hamlets, where a recent study found that 42 percent of children live in poverty, is 100 million pounds in the red.

The sculpture hasn't even been in the borough for 15 years. It was moved to a sculpture park in the north of England when authorities tore down the housing project where it had been placed. The council says just the insurance alone for the massive bronze would be a burden to taxpayers.

"We make this decision with a heavy heart," said Rania Khan, a local councilor who focuses on culture issues. "We have to make tough decisions."

Local authorities throughout the country are being hit by funding cuts as the central government seeks to balance the budget and reduce borrowing. Funding for local government will fall 33 percent in real terms between April 2011 and March 2015, according to the Local Government Association. The Institute for Fiscal Studies says the cuts tend to hit poor, urban areas like Tower Hamlets hardest, because their spending was higher to begin with.

Some 2,000 museums in Britain are local affairs. Bury Council sold a painting by L.S. Lowry in 2006, and Southampton City Council backed down from plans to sell an Auguste Rodin bronze in the face of public protest. The Museums Association has advised the Northampton council to hold off on the sale of an Egyptian funerary monument estimated to be worth 2 million pounds until more consultation can be done.

The depth of the recession and the lack of hope that things will improve soon are fueling the debate.

The latest figures from the Office for Budget Responsibility, an independent agency created in 2010 to advise the government, show the economy is growing more slowly than previously forecast, reducing tax revenue and prolonging the government's austerity program.

One thing is certain: Tower Hamlets, a community of 254,000 people, desperately needs the money.

Khan says she believes Moore, the son of a coal miner and lifelong socialist who died in 1986, would be moved by the plight of her constituents. She knows women who will be hard hit by proposed limits on benefit payments ? people for whom as little as five pounds can make a huge difference ? and families living in housing with mold growing on the walls.

"If he thought the sale of the sculpture would benefit the lives of thousands in Tower Hamlets ... I think he would be in favor," Khan said.

Moore attended art school on a scholarship for ex-servicemen. He became fascinated with the human form, creating works with undulating curves that reflect rolling hills and other features of nature. His most beloved motif was the reclining female figure, like that of Old Flo.

The statue features the graceful draping that Moore traced to his observation of people huddled in the Underground during the Blitz. In a 1966 interview with the BBC, Moore talked about the fear and exhilaration of Londoners sheltering against the Nazi barrage. He had concern for those he was drawing: He never sat sketching but waited until the following day and drew from memory ? rather than capturing people in their makeshift bedrooms.

Alan Wilkinson, one of the foremost Moore scholars, said the artist would have been sympathetic about the hard times in Tower Hamlets, but would want his sculptures seen the way they were intended to be seen ? in public spaces.

"Public sculpture was incredibly important for him," Wilkinson said. "He was very fussy about where it was placed."

Moore sold Old Flo at discount to the London County Council, a forerunner of the city's current administration, in 1962 on condition the statue would be displayed publicly. It was placed at a public housing project.

The East End was one of the areas hardest hit by Nazi bombs, and its residents were directly connected to the work.

Now war memories have faded. The median age of people in Tower Hamlets is 29, the lowest in London, and 43 percent of the population was born outside the U.K., according to the latest census figures.

Old Flo's story hasn't been told to the current generation, said Patrick Brill, an artist who uses the pseudonym Bob and Roberta Smith.

"If we don't cherish these things, we lose a bit of our history," he said. "If you lose your history, you lose a bit of yourself, really."

Still, Old Flo has a fan club. Danny Boyle, director of films such as "Slumdog Millionaire" and "Trainspotting," signed an open letter asking the council to reverse its decision. A flash mob of people dressed as Old Flo appeared at the Tower Hamlets offices in November to protest the sale. Another London borough has laid claim to the statue.

Critics believe money raised by the sale would quickly vanish? and Old Flo would disappear into the private collection of a foreign hedge fund owner or Russian oligarch, taking Moore's message into hiding

Rushanara Ali, a member of Parliament who represents part of Tower Hamlets, raised the issue during a December debate, suggesting the proposal was more the result of "profligacy and extraordinary waste," than tough economic times.

"This bonfire of public art is not the answer," Ali said. "One has to ask, where does this end? What precedents will be set for other areas that may wish to make such sales to deal with financial challenges?"

Noting Moore's interest in the work of Pablo Picasso, Brill said Old Flo was influenced by "Guernica," the 1937 painting that shows the suffering inflicted by war. As such, she still has resonance for the people of Tower Hamlets, an area that has been home to generations of immigrants, including the Bangladeshis who today account for 32 percent of the population.

"Old Flo ... is a very British 'keep calm carry on' image of the same thing as 'Guernica,'" he said. "Old Flo is East London's monument to people seeking sanctuary. She is our 'Guernica.'"

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-03-24-Britain-Moore%20or%20Less/id-4b03297e4e8d4c11b2bc58c44fdc6b1b

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Two of fashion?s best heat-up Miami, Florida!

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Source: http://www.modelsblog.info/2013/03/24/two-of-fashions-best-heat-up-miami-florida/

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Court: Can drug companies pay to delay generics?

FILE - In a Jan. 7, 2008, file photo then-Attorney Donald Verrilli talks to media outside the Supreme Court. Now President Barack Obama's top Supreme Court lawyer, Solicitor General Verilli will argue before the Supreme Court this week whether it is legal for patent-holding pharmaceutical companies to pay rivals, who make generic drugs, to temporarily keep those cheaper versions of their brand-name drugs off the market. The Obama administration is taking the position that the agreements are illegal if they?re based solely on keeping the generic drug out of consumer's hands. (AP Photo/Evan Vucci, File)

FILE - In a Jan. 7, 2008, file photo then-Attorney Donald Verrilli talks to media outside the Supreme Court. Now President Barack Obama's top Supreme Court lawyer, Solicitor General Verilli will argue before the Supreme Court this week whether it is legal for patent-holding pharmaceutical companies to pay rivals, who make generic drugs, to temporarily keep those cheaper versions of their brand-name drugs off the market. The Obama administration is taking the position that the agreements are illegal if they?re based solely on keeping the generic drug out of consumer's hands. (AP Photo/Evan Vucci, File)

FILE - In this Aug. 12, 2011 file photo, Jeremy Lazarus, president-elect of the American Medical Association (AMA) speaks in Portland, Oregon. The Supreme Court will struggle this week with whether it?s legal for patent-holding pharmaceutical companies to pay rivals, who make generic drugs, to temporarily keep those cheaper versions of their brand-name drugs off the market. Now AMA President, Lazarus said in a statement,"The AMA believes that pay-for-delay agreements undermine the balance between spurring innovation through the patent system and fostering competition through the development of generic drugs. Pay for delay must stop to ensure the most cost-effective treatment options are available to patients." (AP Photo/Rick Bowmer, File)

This March 2011 photo provided Actavis Inc. shows Actavis CEO Paul Bisario at the pharmaceutical company's corporate headquarters in Parsippany, N.J. On Monday, March 25, 2013, the U.S. Supreme Court is scheduled to hear arguments of pharmaceutical company interests in recouping billions of dollars spent developing new drugs pitted against the government's desire to get cheaper generic drugs on the market earlier to save American consumers money. "By doing what the FTC wants, you're going to hurt consumers rather than help them," said Bisaro. Fighting between generic and brand-name drugmakers in court is risky and time consuming, he said, while settlements bring certainty, allow generic drug sales years before patents expire and reduce legal costs. (AP Photo/Actavis, Maryanne Russell)

WASHINGTON (AP) ? Federal regulators are pressing the Supreme Court to stop big pharmaceutical corporations from paying generic drug competitors to delay releasing their cheaper versions of brand-name drugs. They argue these deals deny American consumers, usually for years, steep price declines that can top 90 percent.

The Obama administration, backed by consumer groups and the American Medical Association, says these so-called "pay for delay" deals profit the drug companies but harm consumers by adding 3.5 billion annually to their drug bills.

But the pharmaceutical companies counter that they need to preserve longer the billions of dollars in revenue from their patented products in order to recover the billions they spend developing new drugs. And both the large companies and the generic makers say the marketing of generics often is hastened by these deals.

The justices will hear the argument Monday.

Such pay-for-delay deals arise when generic companies file a challenge at the Food and Drug Administration to the patents that give brand-name drugs a 20-year monopoly. The generic drugmakers aim to prove the patent is flawed or otherwise invalid, so they can launch a generic version well before the patent ends.

Brand-name drugmakers then usually sue the generic companies, which sets up what could be years of expensive litigation. When the two sides aren't certain who will win, they often reach a compromise deal that allows the generic company to sell its cheaper copycat drug in a few years ? but years before the drug's patent would expire. Often, that settlement comes with a sizeable payment from the brand-name company to the generic drugmaker.

Numerous brand-name and generic drugmakers and their respective trade groups say the settlements protect their interests but also benefit consumers by bringing inexpensive copycat medicines to market years earlier than they would arrive in any case generic drugmakers took to trial and lost. But federal officials counter that such deals add billions to the drug bills of American patients and taxpayers, compared to what would happen if the generic companies won the lawsuits and could begin marketing right away.

A study by RBC Capital Markets Corp. of 371 cases during 2000-2009 found brand-name companies won 89 at trial compared to 82 won by generic drugmakers. Another 175 ended in settlement deals, and 25 were dropped.

Generic drugs account for about 80 percent of all American prescriptions for medicines and vaccines, but a far smaller percentage of the $325 billion spent by U.S. consumers on drugs each year. Generics saved American patients, taxpayers and the healthcare system an estimated $193 billion in 2011 alone, according to health data firm IMS Health.

But government officials believe the number of potentially anticompetitive patent settlements is increasing. Pay-for-delay deals increased from 28 to 40 in just the last two fiscal years and the deals in fiscal 2012 covered 31 brand-name pharmaceuticals, Federal Trade Commission officials said. Those had combined annual U.S. sales of more than $8.3 billion.

The Obama administration argues the agreements are illegal if they're based solely on keeping the generic drug off the market. Solicitor General Donald Verrilli, speaking at Georgetown Law School recently, noted that once a generic drug gets on the market and competes with a brand-name drug, "the price drops 85 percent." That quickly decimates sales of the brand-name medicine.

"These agreements should actually be considered presumptively unlawful because of the potential effects on consumers," Verrilli said.

In the case before the court, Brussels, Belgium-based Solvay ? now part of a new company called AbbVie Inc. ? reached a deal with generic drugmaker Watson Pharmaceuticals allowing it to launch a cheaper version of Solvay's male hormone drug AndroGel in August 2015. Solvay agreed to pay Watson an estimated $19 million-$30 million annually, government officials said. The patent runs until August 2020. Watson, now called Actavis Inc., agreed to also help sell the brand-name version, AndroGel.

Actavis spokesman David Belian disputed the government's characterization of the agreement with Solvay. Belian said that in addition to licensing agreement over Solvay's Androgel patents, Watson was being compensated for using its sales force to promote Androgel to doctors.

AndroGel, which brought in $1.2 billion last year for AbbVie, is a gel applied to the skin daily to treat low testosterone in men. Low testosterone can affect sex drive, energy level, mood, muscle mass and bone strength.

The FTC called the deal anticompetitive and sued Actavis.

The 11th U.S. Circuit Court of Appeals in Atlanta rejected the government's objections, and the FTC appealed to the Supreme Court.

The federal district and appellate courts both ruled against the government, AbbVie, which is based in North Chicago, Ill., said. "We are confident that these decisions will be upheld by the Supreme Court."

The Generic Pharmaceutical Association's head, Ralph Neas, said the settlements are "pro-consumer, pro-competition and transparent." He said every patent settlement to date has brought a generic drug to market before the relevant patent ended, with two-thirds of the new generic drugs launched in 2010 and 2011 hitting the market early due to a settlement.

"By doing what the FTC wants, you're going to hurt consumers rather than help them," said Paul Bisaro, CEO of Actavis of Parsippany, N.J.

Bisaro said consumers will save an estimated $50 billion just from patent settlements involving Lipitor, the cholesterol-lowering drug made by Pfizer Inc. of New York that reigned for nearly a decade as the world's top-selling drug.

Lipitor's patent ran until 2017, but multiple generic companies challenged it. Pfizer reached a settlement that enabled Actavis and a second company to sell slightly cheaper generic versions starting Nov. 30, 2011 and several other generic drugmakers to begin selling generic Lipitor six months later. The price then plummeted from Pfizer's $375 to $530 for a three-month supply, depending on dosage, to $20 to $40 for generic versions.

Because generic companies tend to challenge patents of every successful drug, the FTC's position would impose onerous legal costs on brand-name drugmakers and limit their ability to fund expensive research to create new drugs, said the Pharmaceutical Research and Manufacturers of America, which represents brand-name drugmakers.

According to the 2010 RBC Capital Markets study, when trial victories, settlements between drugmakers and dropped cases are combined, generic companies were able to bring their product to market before the brand-name drug's patent expired in 76 percent of the 371 drug patent suits decided from 2000 through 2009.

Consumer, doctor and drugstore groups have lined up to support the Obama administration in this case.

"AARP believes it is in the interest of those fifty and older, and indeed the public at large, to hasten the entry of generic prescription drugs to the marketplace," said Ken Zeller, senior attorney with the AARP Foundation Litigation. "Pay-for-delay agreements such as those at issue in this case frustrate that public interest."

The American Medical Association, the giant doctors' group, believes pay-for-delay agreements undermine the balance between spurring innovation through patents and fostering competition through generics, AMA President Dr. Jeremy A., Lazarus said. "Pay for delay must stop to ensure the most cost-effective treatment options are available to patients."

Drugstores also believe pay-for-delay deals "pose considerable harm to patients because they postpone the availability of generic drugs which limits patient access to generic medications," said Chrissy Kopple of the National Association of Chain Drug Stores.

Eight justices will decide this case later this year. Justice Samuel Alito did not take part in considering whether to take this case and is not expected to take part in arguments.

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The case is Federal Trade Commission vs. Actavis, Inc., 12-416.

AP Business Writer Linda A. Johnson in Trenton, N.J., contributed to this report.

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Follow Jesse J. Holland on Twitter at http://www.twitter.com/jessejholland

Follow Linda A. Johnson on Twitter at http://twitter.com/LindaJ_onPharma

Associated Press

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